IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-50868-y.html
   My bibliography  Save this article

Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry

Author

Listed:
  • Akshai Janardhana Kurup

    (iBV)

  • Florian Bailet

    (iBV)

  • Maximilian Fürthauer

    (iBV)

Abstract

Myosin1D (Myo1D) has recently emerged as a conserved regulator of animal Left-Right (LR) asymmetry that governs the morphogenesis of the vertebrate central LR Organizer (LRO). In addition to Myo1D, the zebrafish genome encodes the closely related Myo1G. Here we show that while Myo1G also controls LR asymmetry, it does so through an entirely different mechanism. Myo1G promotes the Nodal-mediated transfer of laterality information from the LRO to target tissues. At the cellular level, Myo1G is associated with endosomes positive for the TGFβ signaling adapter SARA. myo1g mutants have fewer SARA-positive Activin receptor endosomes and a reduced responsiveness to Nodal ligands that results in a delay of left-sided Nodal propagation and tissue-specific laterality defects in organs that are most distant from the LRO. Additionally, Myo1G promotes signaling by different Nodal ligands in specific biological contexts. Our findings therefore identify Myo1G as a context-dependent regulator of the Nodal signaling pathway.

Suggested Citation

  • Akshai Janardhana Kurup & Florian Bailet & Maximilian Fürthauer, 2024. "Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50868-y
    DOI: 10.1038/s41467-024-50868-y
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-50868-y
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-50868-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Jeffrey J. Essner & Kyle J. Vogan & Molly K. Wagner & Clifford J. Tabin & H. Joseph Yost & Martina Brueckner, 2002. "Conserved function for embryonic nodal cilia," Nature, Nature, vol. 418(6893), pages 37-38, July.
    2. Reiko Kuroda & Bunshiro Endo & Masanori Abe & Miho Shimizu, 2009. "Chiral blastomere arrangement dictates zygotic left–right asymmetry pathway in snails," Nature, Nature, vol. 462(7274), pages 790-794, December.
    3. Manush Saydmohammed & Hisato Yagi & Michael Calderon & Madeline J. Clark & Timothy Feinstein & Ming Sun & Donna B. Stolz & Simon C. Watkins & Jeffrey D. Amack & Cecilia W. Lo & Michael Tsang, 2018. "Vertebrate myosin 1d regulates left–right organizer morphogenesis and laterality," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    4. Pauline Spéder & Géza Ádám & Stéphane Noselli, 2006. "Type ID unconventional myosin controls left–right asymmetry in Drosophila," Nature, Nature, vol. 440(7085), pages 803-807, April.
    5. Bernard Thisse & Christopher V. E. Wright & Christine Thisse, 2000. "Activin- and Nodal-related factors control antero–posterior patterning of the zebrafish embryo," Nature, Nature, vol. 403(6768), pages 425-428, January.
    6. Ying Gong & Chunhui Mo & Scott E. Fraser, 2004. "Planar cell polarity signalling controls cell division orientation during zebrafish gastrulation," Nature, Nature, vol. 430(7000), pages 689-693, August.
    7. Katsura Minegishi & Benjamin Rothé & Kaoru R. Komatsu & Hiroki Ono & Yayoi Ikawa & Hiromi Nishimura & Takanobu A. Katoh & Eriko Kajikawa & Xiaorei Sai & Emi Miyashita & Katsuyoshi Takaoka & Kana Bando, 2021. "Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    8. Shunya Hozumi & Reo Maeda & Kiichiro Taniguchi & Maiko Kanai & Syuichi Shirakabe & Takeshi Sasamura & Pauline Spéder & Stéphane Noselli & Toshiro Aigaki & Ryutaro Murakami & Kenji Matsuno, 2006. "An unconventional myosin in Drosophila reverses the default handedness in visceral organs," Nature, Nature, vol. 440(7085), pages 798-802, April.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. F. Lapraz & C. Boutres & C. Fixary-Schuster & B. R. Queiroz & P. Y. Plaçais & D. Cerezo & F. Besse & T. Préat & S. Noselli, 2023. "Asymmetric activity of NetrinB controls laterality of the Drosophila brain," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Yee Han Tee & Wei Jia Goh & Xianbin Yong & Hui Ting Ong & Jinrong Hu & Ignacius Yan Yun Tay & Shidong Shi & Salma Jalal & Samuel F. H. Barnett & Pakorn Kanchanawong & Wenmao Huang & Jie Yan & Yong Ann, 2023. "Actin polymerisation and crosslinking drive left-right asymmetry in single cell and cell collectives," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Sebastian A Sandersius & Manli Chuai & Cornelis J Weijer & Timothy J Newman, 2011. "Correlating Cell Behavior with Tissue Topology in Embryonic Epithelia," PLOS ONE, Public Library of Science, vol. 6(4), pages 1-11, April.
    4. Yingzi Li & Hammad Naveed & Sema Kachalo & Lisa X Xu & Jie Liang, 2012. "Mechanisms of Regulating Cell Topology in Proliferating Epithelia: Impact of Division Plane, Mechanical Forces, and Cell Memory," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-10, August.
    5. Jaeho Yoon & Jian Sun & Moonsup Lee & Yoo-Seok Hwang & Ira O. Daar, 2023. "Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    6. Bernd Boehm & Henrik Westerberg & Gaja Lesnicar-Pucko & Sahdia Raja & Michael Rautschka & James Cotterell & Jim Swoger & James Sharpe, 2010. "The Role of Spatially Controlled Cell Proliferation in Limb Bud Morphogenesis," PLOS Biology, Public Library of Science, vol. 8(7), pages 1-21, July.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50868-y. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.