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An unconventional myosin in Drosophila reverses the default handedness in visceral organs

Author

Listed:
  • Shunya Hozumi

    (Department of Biological Science and Technology)

  • Reo Maeda

    (Department of Biological Science and Technology)

  • Kiichiro Taniguchi

    (Department of Biological Science and Technology)

  • Maiko Kanai

    (Department of Biological Science and Technology)

  • Syuichi Shirakabe

    (Department of Biological Science and Technology)

  • Takeshi Sasamura

    (Department of Biological Science and Technology)

  • Pauline Spéder

    (University of Nice Sophia-Antipolis
    University of Nice Sophia-Antipolis)

  • Stéphane Noselli

    (University of Nice Sophia-Antipolis
    University of Nice Sophia-Antipolis)

  • Toshiro Aigaki

    (Tokyo Metropolitan University)

  • Ryutaro Murakami

    (Yamaguchi University)

  • Kenji Matsuno

    (Department of Biological Science and Technology
    Tokyo University of Science)

Abstract

All right now From flies to humans, the left and right side of the body plan differs. Exactly how symmetry is broken in the early embryo is a mystery. But now two groups working independently report a genetic defect in the fly that may help uncover the mechanism. Both groups studied a mutant with reversed looping of the viscera, and discovered that the mutation lies in an unconventional myosin. Myosin directs right-handed looping and represses the default left-handed fate. This discovery now links actin-based molecular motors and the actin cytoskeleton to left–right patterning in vertebrates.

Suggested Citation

  • Shunya Hozumi & Reo Maeda & Kiichiro Taniguchi & Maiko Kanai & Syuichi Shirakabe & Takeshi Sasamura & Pauline Spéder & Stéphane Noselli & Toshiro Aigaki & Ryutaro Murakami & Kenji Matsuno, 2006. "An unconventional myosin in Drosophila reverses the default handedness in visceral organs," Nature, Nature, vol. 440(7085), pages 798-802, April.
    • Handle: RePEc:nat:nature:v:440:y:2006:i:7085:d:10.1038_nature04625
    DOI: 10.1038/nature04625
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    Cited by:

    1. Yee Han Tee & Wei Jia Goh & Xianbin Yong & Hui Ting Ong & Jinrong Hu & Ignacius Yan Yun Tay & Shidong Shi & Salma Jalal & Samuel F. H. Barnett & Pakorn Kanchanawong & Wenmao Huang & Jie Yan & Yong Ann, 2023. "Actin polymerisation and crosslinking drive left-right asymmetry in single cell and cell collectives," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. F. Lapraz & C. Boutres & C. Fixary-Schuster & B. R. Queiroz & P. Y. Plaçais & D. Cerezo & F. Besse & T. Préat & S. Noselli, 2023. "Asymmetric activity of NetrinB controls laterality of the Drosophila brain," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Akshai Janardhana Kurup & Florian Bailet & Maximilian Fürthauer, 2024. "Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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