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Planar cell polarity signalling controls cell division orientation during zebrafish gastrulation

Author

Listed:
  • Ying Gong

    (Beckman Institute, California Institute of Technology
    California Institute of Technology)

  • Chunhui Mo

    (California Institute of Technology)

  • Scott E. Fraser

    (Beckman Institute, California Institute of Technology
    California Institute of Technology)

Abstract

Oriented cell division is an integral part of pattern development in processes ranging from asymmetric segregation of cell-fate determinants to the shaping of tissues1,2. Despite proposals that it has an important function in tissue elongation3,4, the mechanisms regulating division orientation have been little studied outside of the invertebrates Caenorhabditis elegans and Drosophila melanogaster1. Here, we have analysed mitotic divisions during zebrafish gastrulation using in vivo confocal imaging and found that cells in dorsal tissues preferentially divide along the animal–vegetal axis of the embryo. Establishment of this animal–vegetal polarity requires the Wnt pathway components Silberblick/Wnt11, Dishevelled and Strabismus. Our findings demonstrate an important role for non-canonical Wnt signalling in oriented cell division during zebrafish gastrulation, and indicate that oriented cell division is a driving force for axis elongation. Furthermore, we propose that non-canonical Wnt signalling has a conserved role in vertebrate axis elongation, orienting both cell intercalation and mitotic division.

Suggested Citation

  • Ying Gong & Chunhui Mo & Scott E. Fraser, 2004. "Planar cell polarity signalling controls cell division orientation during zebrafish gastrulation," Nature, Nature, vol. 430(7000), pages 689-693, August.
    • Handle: RePEc:nat:nature:v:430:y:2004:i:7000:d:10.1038_nature02796
    DOI: 10.1038/nature02796
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    Cited by:

    1. Akshai Janardhana Kurup & Florian Bailet & Maximilian Fürthauer, 2024. "Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Yingzi Li & Hammad Naveed & Sema Kachalo & Lisa X Xu & Jie Liang, 2012. "Mechanisms of Regulating Cell Topology in Proliferating Epithelia: Impact of Division Plane, Mechanical Forces, and Cell Memory," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-10, August.
    3. Sebastian A Sandersius & Manli Chuai & Cornelis J Weijer & Timothy J Newman, 2011. "Correlating Cell Behavior with Tissue Topology in Embryonic Epithelia," PLOS ONE, Public Library of Science, vol. 6(4), pages 1-11, April.
    4. Bernd Boehm & Henrik Westerberg & Gaja Lesnicar-Pucko & Sahdia Raja & Michael Rautschka & James Cotterell & Jim Swoger & James Sharpe, 2010. "The Role of Spatially Controlled Cell Proliferation in Limb Bud Morphogenesis," PLOS Biology, Public Library of Science, vol. 8(7), pages 1-21, July.
    5. Jaeho Yoon & Jian Sun & Moonsup Lee & Yoo-Seok Hwang & Ira O. Daar, 2023. "Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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