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Type ID unconventional myosin controls left–right asymmetry in Drosophila

Author

Listed:
  • Pauline Spéder

    (University of Nice Sophia-Antipolis
    University of Nice Sophia-Antipolis)

  • Géza Ádám

    (University of Nice Sophia-Antipolis
    University of Nice Sophia-Antipolis
    Biological Research Center of the Hungarian Academy of Sciences)

  • Stéphane Noselli

    (University of Nice Sophia-Antipolis
    University of Nice Sophia-Antipolis)

Abstract

All right now From flies to humans, the left and right side of the body plan differs. Exactly how symmetry is broken in the early embryo is a mystery. But now two groups working independently report a genetic defect in the fly that may help uncover the mechanism. Both groups studied a mutant with reversed looping of the viscera, and discovered that the mutation lies in an unconventional myosin. Myosin directs right-handed looping and represses the default left-handed fate. This discovery now links actin-based molecular motors and the actin cytoskeleton to left–right patterning in vertebrates.

Suggested Citation

  • Pauline Spéder & Géza Ádám & Stéphane Noselli, 2006. "Type ID unconventional myosin controls left–right asymmetry in Drosophila," Nature, Nature, vol. 440(7085), pages 803-807, April.
    • Handle: RePEc:nat:nature:v:440:y:2006:i:7085:d:10.1038_nature04623
    DOI: 10.1038/nature04623
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    Cited by:

    1. Yee Han Tee & Wei Jia Goh & Xianbin Yong & Hui Ting Ong & Jinrong Hu & Ignacius Yan Yun Tay & Shidong Shi & Salma Jalal & Samuel F. H. Barnett & Pakorn Kanchanawong & Wenmao Huang & Jie Yan & Yong Ann, 2023. "Actin polymerisation and crosslinking drive left-right asymmetry in single cell and cell collectives," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. F. Lapraz & C. Boutres & C. Fixary-Schuster & B. R. Queiroz & P. Y. Plaçais & D. Cerezo & F. Besse & T. Préat & S. Noselli, 2023. "Asymmetric activity of NetrinB controls laterality of the Drosophila brain," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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