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A conserved oomycete effector RxLR23 triggers plant defense responses by targeting ERD15La to release NbNAC68

Author

Listed:
  • Hui Sheng

    (Shandong Agricultural University)

  • Congcong Ai

    (Shandong Agricultural University)

  • Cancan Yang

    (Shandong Agricultural University)

  • Chunyuan Zhu

    (Shandong Agricultural University)

  • Zhe Meng

    (Shandong Normal University)

  • Fengzhi Wu

    (Northeast Agricultural University)

  • Xiaodan Wang

    (China Agricultural University)

  • Daolong Dou

    (Nanjing Agricultural University)

  • Paul F. Morris

    (Bowling Green State University)

  • Xiuguo Zhang

    (Shandong Agricultural University)

Abstract

Oomycete pathogens deliver many effectors to enhance virulence or suppress plant immunity. Plant immune networks are interconnected, in which a few effectors can trigger a strong defense response when recognized by immunity-related proteins. How effectors activate plant defense response remains poorly understood. Here we report Phytophthora capsici effector RxLR23KM can induce plant cell death and plant immunity. RxLR23KM specifically binds to ERD15La, a regulator of abscisic acid and salicylic acid pathway, and the binding intensity depends on the amino acid residues (K93 and M320). NbNAC68, a downstream protein of ERD15La, can stimulate plant immunity that is compromised after binding with ERD15La. Silencing of NbNAC68 substantially prevents the activation of plant defense response. RxLR23KM binds to ERD15La, releasing NbNAC68 to activate plant immunity. These findings highlight a strategy of plant defense response that ERD15La as a central regulator coordinates RxLR23KM to regulate NbNAC68-triggered plant immunity.

Suggested Citation

  • Hui Sheng & Congcong Ai & Cancan Yang & Chunyuan Zhu & Zhe Meng & Fengzhi Wu & Xiaodan Wang & Daolong Dou & Paul F. Morris & Xiuguo Zhang, 2024. "A conserved oomycete effector RxLR23 triggers plant defense responses by targeting ERD15La to release NbNAC68," Nature Communications, Nature, vol. 15(1), pages 1-23, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50782-3
    DOI: 10.1038/s41467-024-50782-3
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    1. Petra C. Boevink & Xiaodan Wang & Hazel McLellan & Qin He & Shaista Naqvi & Miles R. Armstrong & Wei Zhang & Ingo Hein & Eleanor M. Gilroy & Zhendong Tian & Paul R. J. Birch, 2016. "A Phytophthora infestans RXLR effector targets plant PP1c isoforms that promote late blight disease," Nature Communications, Nature, vol. 7(1), pages 1-14, April.
    2. Brian J. Haas & Sophien Kamoun & Michael C. Zody & Rays H. Y. Jiang & Robert E. Handsaker & Liliana M. Cano & Manfred Grabherr & Chinnappa D. Kodira & Sylvain Raffaele & Trudy Torto-Alalibo & Tolga O., 2009. "Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans," Nature, Nature, vol. 461(7262), pages 393-398, September.
    3. Jonathan D. G. Jones & Jeffery L. Dangl, 2006. "The plant immune system," Nature, Nature, vol. 444(7117), pages 323-329, November.
    4. Maofeng Jing & Baodian Guo & Haiyang Li & Bo Yang & Haonan Wang & Guanghui Kong & Yao Zhao & Huawei Xu & Yan Wang & Wenwu Ye & Suomeng Dong & Yongli Qiao & Brett M. Tyler & Wenbo Ma & Yuanchao Wang, 2016. "A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins," Nature Communications, Nature, vol. 7(1), pages 1-17, September.
    5. Stephen C. Whisson & Petra C. Boevink & Lucy Moleleki & Anna O. Avrova & Juan G. Morales & Eleanor M. Gilroy & Miles R. Armstrong & Severine Grouffaud & Pieter van West & Sean Chapman & Ingo Hein & Ia, 2007. "A translocation signal for delivery of oomycete effector proteins into host plant cells," Nature, Nature, vol. 450(7166), pages 115-118, November.
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