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A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins

Author

Listed:
  • Maofeng Jing

    (Nanjing Agricultural University
    Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education))

  • Baodian Guo

    (Nanjing Agricultural University
    Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education))

  • Haiyang Li

    (Nanjing Agricultural University
    Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education))

  • Bo Yang

    (Nanjing Agricultural University
    Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education))

  • Haonan Wang

    (Nanjing Agricultural University
    Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education))

  • Guanghui Kong

    (Nanjing Agricultural University
    Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education))

  • Yao Zhao

    (Nanjing Agricultural University
    Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education))

  • Huawei Xu

    (Nanjing Agricultural University
    Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education))

  • Yan Wang

    (Nanjing Agricultural University
    Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education))

  • Wenwu Ye

    (Nanjing Agricultural University
    Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education))

  • Suomeng Dong

    (Nanjing Agricultural University
    Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education))

  • Yongli Qiao

    (Institute of Crop Science, Chinese Academy of Agricultural Sciences)

  • Brett M. Tyler

    (Oregon State University)

  • Wenbo Ma

    (University of California
    Center for Plant Cell Biology, University of California)

  • Yuanchao Wang

    (Nanjing Agricultural University
    Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education))

Abstract

Phytophthora pathogens secrete an array of specific effector proteins to manipulate host innate immunity to promote pathogen colonization. However, little is known about the host targets of effectors and the specific mechanisms by which effectors increase susceptibility. Here we report that the soybean pathogen Phytophthora sojae uses an essential effector PsAvh262 to stabilize endoplasmic reticulum (ER)-luminal binding immunoglobulin proteins (BiPs), which act as negative regulators of plant resistance to Phytophthora. By stabilizing BiPs, PsAvh262 suppresses ER stress-triggered cell death and facilitates Phytophthora infection. The direct targeting of ER stress regulators may represent a common mechanism of host manipulation by microbes.

Suggested Citation

  • Maofeng Jing & Baodian Guo & Haiyang Li & Bo Yang & Haonan Wang & Guanghui Kong & Yao Zhao & Huawei Xu & Yan Wang & Wenwu Ye & Suomeng Dong & Yongli Qiao & Brett M. Tyler & Wenbo Ma & Yuanchao Wang, 2016. "A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins," Nature Communications, Nature, vol. 7(1), pages 1-17, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11685
    DOI: 10.1038/ncomms11685
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    Cited by:

    1. Hui Sheng & Congcong Ai & Cancan Yang & Chunyuan Zhu & Zhe Meng & Fengzhi Wu & Xiaodan Wang & Daolong Dou & Paul F. Morris & Xiuguo Zhang, 2024. "A conserved oomycete effector RxLR23 triggers plant defense responses by targeting ERD15La to release NbNAC68," Nature Communications, Nature, vol. 15(1), pages 1-23, December.

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