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A translocation signal for delivery of oomycete effector proteins into host plant cells

Author

Listed:
  • Stephen C. Whisson

    (Plant Pathology Programme, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK)

  • Petra C. Boevink

    (Plant Pathology Programme, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK)

  • Lucy Moleleki

    (Plant Pathology Programme, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK)

  • Anna O. Avrova

    (Plant Pathology Programme, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK)

  • Juan G. Morales

    (Plant Pathology Programme, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK)

  • Eleanor M. Gilroy

    (Plant Pathology Programme, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK)

  • Miles R. Armstrong

    (Plant Pathology Programme, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK)

  • Severine Grouffaud

    (Plant Pathology Programme, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK
    Aberdeen Oomycete Group, University of Aberdeen, Institute of Medical Sciences)

  • Pieter van West

    (Aberdeen Oomycete Group, University of Aberdeen, Institute of Medical Sciences)

  • Sean Chapman

    (Plant Pathology Programme, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK)

  • Ingo Hein

    (Plant Pathology Programme, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK)

  • Ian K. Toth

    (Plant Pathology Programme, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK)

  • Leighton Pritchard

    (Plant Pathology Programme, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK)

  • Paul R. J. Birch

    (Plant Pathology Programme, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK)

Abstract

Common entrance Many plant and animal pathogens evade host immunity systems by injecting virulence or effector proteins into the host cells. A study of the fungus Phytophthora infestans, the potato blight pathogen, has identified a conserved peptide motif in effector proteins that is required for movement of effectors from specialized infection structures called haustoria into plant cells. This sequence, called RXLR-EER, was recently reported to be required for the translocation of the malarial parasite Plasmodium falciparum into human erythrocytes. These studies suggest that different eukaryotic pathogens use equivalent targeting signals to deliver their effector proteins.

Suggested Citation

  • Stephen C. Whisson & Petra C. Boevink & Lucy Moleleki & Anna O. Avrova & Juan G. Morales & Eleanor M. Gilroy & Miles R. Armstrong & Severine Grouffaud & Pieter van West & Sean Chapman & Ingo Hein & Ia, 2007. "A translocation signal for delivery of oomycete effector proteins into host plant cells," Nature, Nature, vol. 450(7166), pages 115-118, November.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7166:d:10.1038_nature06203
    DOI: 10.1038/nature06203
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    Citations

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    Cited by:

    1. Ana Cruz-Silva & Andreia Figueiredo & Mónica Sebastiana, 2021. "First Insights into the Effect of Mycorrhizae on the Expression of Pathogen Effectors during the Infection of Grapevine with Plasmopara viticola," Sustainability, MDPI, vol. 13(3), pages 1-12, January.
    2. Carly F Summers & Colwyn M Gulliford & Craig H Carlson & Jacquelyn A Lillis & Maryn O Carlson & Lance Cadle-Davidson & David H Gent & Christine D Smart, 2015. "Identification of Genetic Variation between Obligate Plant Pathogens Pseudoperonospora cubensis and P. humuli Using RNA Sequencing and Genotyping-By-Sequencing," PLOS ONE, Public Library of Science, vol. 10(11), pages 1-19, November.
    3. Joe Win & Ksenia V Krasileva & Sophien Kamoun & Ken Shirasu & Brian J Staskawicz & Mark J Banfield, 2012. "Sequence Divergent RXLR Effectors Share a Structural Fold Conserved across Plant Pathogenic Oomycete Species," PLOS Pathogens, Public Library of Science, vol. 8(1), pages 1-4, January.
    4. Hui Sheng & Congcong Ai & Cancan Yang & Chunyuan Zhu & Zhe Meng & Fengzhi Wu & Xiaodan Wang & Daolong Dou & Paul F. Morris & Xiuguo Zhang, 2024. "A conserved oomycete effector RxLR23 triggers plant defense responses by targeting ERD15La to release NbNAC68," Nature Communications, Nature, vol. 15(1), pages 1-23, December.
    5. Diane G O Saunders & Joe Win & Liliana M Cano & Les J Szabo & Sophien Kamoun & Sylvain Raffaele, 2012. "Using Hierarchical Clustering of Secreted Protein Families to Classify and Rank Candidate Effectors of Rust Fungi," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-14, January.

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