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Sororin is an evolutionary conserved antagonist of WAPL

Author

Listed:
  • Ignacio Prusén Mota

    (Vienna Biocenter Campus (VBC)
    Department of Chromosome Biology
    a Doctoral School of the University of Vienna and the Medical University of Vienna)

  • Marta Galova

    (Vienna Biocenter (VBC))

  • Alexander Schleiffer

    (Vienna Biocenter (VBC))

  • Tan-Trung Nguyen

    (Vienna Biocenter Campus (VBC)
    Department of Chromosome Biology)

  • Ines Kovacikova

    (Department of Chromosome Biology)

  • Carolina Farias Saad

    (Vienna Biocenter Campus (VBC)
    Department of Chromosome Biology
    a Doctoral School of the University of Vienna and the Medical University of Vienna)

  • Gabriele Litos

    (Vienna Biocenter (VBC))

  • Tomoko Nishiyama

    (Vienna Biocenter (VBC))

  • Juraj Gregan

    (Department of Chromosome Biology
    University of Natural Resources and Life Sciences)

  • Jan-Michael Peters

    (Vienna Biocenter (VBC))

  • Peter Schlögelhofer

    (Vienna Biocenter Campus (VBC)
    Department of Chromosome Biology)

Abstract

Cohesin mediates sister chromatid cohesion to enable chromosome segregation and DNA damage repair. To perform these functions, cohesin needs to be protected from WAPL, which otherwise releases cohesin from DNA. It has been proposed that cohesin is protected from WAPL by SORORIN. However, in vivo evidence for this antagonism is missing and SORORIN is only known to exist in vertebrates and insects. It is therefore unknown how important and widespread SORORIN’s functions are. Here we report the identification of SORORIN orthologs in Schizosaccharomyces pombe (Sor1) and Arabidopsis thaliana (AtSORORIN). sor1Δ mutants display cohesion defects, which are partially alleviated by wpl1Δ. Atsororin mutant plants display dwarfism, tissue specific cohesion defects and chromosome mis-segregation. Furthermore, Atsororin mutant plants are sterile and separate sister chromatids prematurely at anaphase I. The somatic, but not the meiotic deficiencies can be alleviated by loss of WAPL. These results provide in vivo evidence for SORORIN antagonizing WAPL, reveal that SORORIN is present in organisms beyond the animal kingdom and indicate that it has acquired tissue specific functions in plants.

Suggested Citation

  • Ignacio Prusén Mota & Marta Galova & Alexander Schleiffer & Tan-Trung Nguyen & Ines Kovacikova & Carolina Farias Saad & Gabriele Litos & Tomoko Nishiyama & Juraj Gregan & Jan-Michael Peters & Peter Sc, 2024. "Sororin is an evolutionary conserved antagonist of WAPL," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49178-0
    DOI: 10.1038/s41467-024-49178-0
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    References listed on IDEAS

    as
    1. Chao Yang & Yuki Hamamura & Kostika Sofroni & Franziska Böwer & Sara Christina Stolze & Hirofumi Nakagami & Arp Schnittger, 2019. "SWITCH 1/DYAD is a WINGS APART-LIKE antagonist that maintains sister chromatid cohesion in meiosis," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
    2. Yan Li & Judith H. I. Haarhuis & Ángela Sedeño Cacciatore & Roel Oldenkamp & Marjon S. Ruiten & Laureen Willems & Hans Teunissen & Kyle W. Muir & Elzo Wit & Benjamin D. Rowland & Daniel Panne, 2020. "The structural basis for cohesin–CTCF-anchored loops," Nature, Nature, vol. 578(7795), pages 472-476, February.
    3. Yasuto Murayama & Frank Uhlmann, 2014. "Biochemical reconstitution of topological DNA binding by the cohesin ring," Nature, Nature, vol. 505(7483), pages 367-371, January.
    4. Tomoya S. Kitajima & Takeshi Sakuno & Kei-ichiro Ishiguro & Shun-ichiro Iemura & Tohru Natsume & Shigehiro A. Kawashima & Yoshinori Watanabe, 2006. "Shugoshin collaborates with protein phosphatase 2A to protect cohesin," Nature, Nature, vol. 441(7089), pages 46-52, May.
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