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Meiosis-specific distal cohesion site decoupled from the kinetochore

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Listed:
  • Bo Pan

    (National Institutes of Health)

  • Melania Bruno

    (National Institutes of Health)

  • Todd S. Macfarlan

    (National Institutes of Health)

  • Takashi Akera

    (National Institutes of Health)

Abstract

Primary constriction of the M-phase chromosome serves as a marker for the kinetochore position. Underlying this observation is the concept that the kinetochore is spatially linked with the pericentromere where sister-chromatids are cohered. Here, we find an unconventional chromatid-cohesion pattern in Peromyscus oocytes, with sister chromatids cohered at a chromosome end, spatially separated from the kinetochore. This distal locus enriches cohesin protectors specifically during meiosis, and chromosomes with this additional cohesion site exhibit enhanced cohesin protection at anaphase I compared to those without it, implying an adaptive evolution to ensure cohesion during meiosis. The distal locus corresponds to an additional centromeric satellite block, located far from the satellite block building the kinetochore. Analyses on three Peromyscus species reveal that the internal satellite consistently assembles the kinetochore in mitosis and meiosis, whereas the distal satellite selectively enriches cohesin protectors in meiosis to promote cohesion. Our study demonstrates that cohesion regulation is flexible, controlling chromosome segregation in a cell-type dependent manner.

Suggested Citation

  • Bo Pan & Melania Bruno & Todd S. Macfarlan & Takashi Akera, 2025. "Meiosis-specific distal cohesion site decoupled from the kinetochore," Nature Communications, Nature, vol. 16(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-57438-w
    DOI: 10.1038/s41467-025-57438-w
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    1. Christian G. Riedel & Vittorio L. Katis & Yuki Katou & Saori Mori & Takehiko Itoh & Wolfgang Helmhart & Marta Gálová & Mark Petronczki & Juraj Gregan & Bulent Cetin & Ingrid Mudrak & Egon Ogris & Karl, 2006. "Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I," Nature, Nature, vol. 441(7089), pages 53-61, May.
    2. Tianyu Wu & Simon I. R. Lane & Stephanie L. Morgan & Keith T. Jones, 2018. "Spindle tubulin and MTOC asymmetries may explain meiotic drive in oocytes," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    3. Tomoya S. Kitajima & Takeshi Sakuno & Kei-ichiro Ishiguro & Shun-ichiro Iemura & Tohru Natsume & Shigehiro A. Kawashima & Yoshinori Watanabe, 2006. "Shugoshin collaborates with protein phosphatase 2A to protect cohesin," Nature, Nature, vol. 441(7089), pages 46-52, May.
    4. Warif El Yakoubi & Takashi Akera, 2023. "Condensin dysfunction is a reproductive isolating barrier in mice," Nature, Nature, vol. 623(7986), pages 347-355, November.
    5. Yogo Sakakibara & Shu Hashimoto & Yoshiharu Nakaoka & Anna Kouznetsova & Christer Höög & Tomoya S. Kitajima, 2015. "Bivalent separation into univalents precedes age-related meiosis I errors in oocytes," Nature Communications, Nature, vol. 6(1), pages 1-8, November.
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