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Gene expression signatures in blood from a West African sepsis cohort define host response phenotypes

Author

Listed:
  • Josh G. Chenoweth

    (The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.)

  • Carlo Colantuoni

    (Johns Hopkins School of Medicine)

  • Deborah A. Striegel

    (The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.)

  • Pavol Genzor

    (The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.)

  • Joost Brandsma

    (The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.)

  • Paul W. Blair

    (The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Uniformed Services University)

  • Subramaniam Krishnan

    (The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.)

  • Elizabeth Chiyka

    (The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.)

  • Mehran Fazli

    (The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.)

  • Rittal Mehta

    (The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.)

  • Michael Considine

    (Johns Hopkins University)

  • Leslie Cope

    (Johns Hopkins University)

  • Audrey C. Knight

    (Johns Hopkins School of Medicine)

  • Anissa Elayadi

    (The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.)

  • Anne Fox

    (Naval Medical Research Unit EURAFCENT Ghana detachment)

  • Ronna Hertzano

    (National Institutes of Health)

  • Andrew G. Letizia

    (Naval Medical Research Unit EURAFCENT Ghana detachment)

  • Alex Owusu-Ofori

    (Komfo Anokye Teaching Hospital (KATH)
    Kwame Nkrumah University of Science and Technology (KNUST))

  • Isaac Boakye

    (KATH)

  • Albert A. Aduboffour

    (Komfo Anokye Teaching Hospital (KATH))

  • Daniel Ansong

    (KATH
    KNUST)

  • Eno Biney

    (KATH)

  • George Oduro

    (KATH)

  • Kevin L. Schully

    (Naval Medical Research Command-Frederick)

  • Danielle V. Clark

    (The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.)

Abstract

Our limited understanding of the pathophysiological mechanisms that operate during sepsis is an obstacle to rational treatment and clinical trial design. There is a critical lack of data from low- and middle-income countries where the sepsis burden is increased which inhibits generalized strategies for therapeutic intervention. Here we perform RNA sequencing of whole blood to investigate longitudinal host response to sepsis in a Ghanaian cohort. Data dimensional reduction reveals dynamic gene expression patterns that describe cell type-specific molecular phenotypes including a dysregulated myeloid compartment shared between sepsis and COVID-19. The gene expression signatures reported here define a landscape of host response to sepsis that supports interventions via targeting immunophenotypes to improve outcomes.

Suggested Citation

  • Josh G. Chenoweth & Carlo Colantuoni & Deborah A. Striegel & Pavol Genzor & Joost Brandsma & Paul W. Blair & Subramaniam Krishnan & Elizabeth Chiyka & Mehran Fazli & Rittal Mehta & Michael Considine &, 2024. "Gene expression signatures in blood from a West African sepsis cohort define host response phenotypes," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48821-0
    DOI: 10.1038/s41467-024-48821-0
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    References listed on IDEAS

    as
    1. Francesco Vallania & Andrew Tam & Shane Lofgren & Steven Schaffert & Tej D. Azad & Erika Bongen & Winston Haynes & Meia Alsup & Michael Alonso & Mark Davis & Edgar Engleman & Purvesh Khatri, 2018. "Leveraging heterogeneity across multiple datasets increases cell-mixture deconvolution accuracy and reduces biological and technical biases," Nature Communications, Nature, vol. 9(1), pages 1-8, December.
    2. Charles R. Harris & K. Jarrod Millman & Stéfan J. Walt & Ralf Gommers & Pauli Virtanen & David Cournapeau & Eric Wieser & Julian Taylor & Sebastian Berg & Nathaniel J. Smith & Robert Kern & Matti Picu, 2020. "Array programming with NumPy," Nature, Nature, vol. 585(7825), pages 357-362, September.
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