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Parental experiences orchestrate locust egg hatching synchrony by regulating nuclear export of precursor miRNA

Author

Listed:
  • Ya′nan Zhu

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Jing He

    (Chinese Academy of Sciences)

  • Jiawen Wang

    (Chinese Academy of Sciences)

  • Wei Guo

    (Chinese Academy of Sciences)

  • Hongran Liu

    (Chinese Academy of Sciences)

  • Zhuoran Song

    (Chinese Academy of Sciences)

  • Le Kang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Hebei University)

Abstract

Parental experiences can affect the phenotypic plasticity of offspring. In locusts, the population density that adults experience regulates the number and hatching synchrony of their eggs, contributing to locust outbreaks. However, the pathway of signal transmission from parents to offspring remains unclear. Here, we find that transcription factor Forkhead box protein N1 (FOXN1) responds to high population density and activates the polypyrimidine tract-binding protein 1 (Ptbp1) in locusts. FOXN1–PTBP1 serves as an upstream regulator of miR-276, a miRNA to control egg-hatching synchrony. PTBP1 boosts the nucleo-cytoplasmic transport of pre-miR-276 in a “CU motif”-dependent manner, by collaborating with the primary exportin protein exportin 5 (XPO5). Enhanced nuclear export of pre-miR-276 elevates miR-276 expression in terminal oocytes, where FOXN1 activates Ptbp1 and leads to egg-hatching synchrony in response to high population density. Additionally, PTBP1-prompted nuclear export of pre-miR-276 is conserved in insects, implying a ubiquitous mechanism to mediate transgenerational effects.

Suggested Citation

  • Ya′nan Zhu & Jing He & Jiawen Wang & Wei Guo & Hongran Liu & Zhuoran Song & Le Kang, 2024. "Parental experiences orchestrate locust egg hatching synchrony by regulating nuclear export of precursor miRNA," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48658-7
    DOI: 10.1038/s41467-024-48658-7
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