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A microRNA component of the p53 tumour suppressor network

Author

Listed:
  • Lin He

    (Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

  • Xingyue He

    (Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Program in Genetics, Stony Brook University, Stony Brook, New York 11794, USA)

  • Lee P. Lim

    (Rosetta Inpharmatics, 401 Terry Avenue N., Seattle, Washington 98109, USA)

  • Elisa de Stanchina

    (Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Present address: Memorial Sloan-Kettering Cancer Center, 415 East 68th Street, New York, New York 10021, USA.)

  • Zhenyu Xuan

    (Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

  • Yu Liang

    (Advanced Research & Technology, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA)

  • Wen Xue

    (Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

  • Lars Zender

    (Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

  • Jill Magnus

    (Rosetta Inpharmatics, 401 Terry Avenue N., Seattle, Washington 98109, USA)

  • Dana Ridzon

    (Advanced Research & Technology, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA)

  • Aimee L. Jackson

    (Rosetta Inpharmatics, 401 Terry Avenue N., Seattle, Washington 98109, USA)

  • Peter S. Linsley

    (Rosetta Inpharmatics, 401 Terry Avenue N., Seattle, Washington 98109, USA)

  • Caifu Chen

    (Advanced Research & Technology, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA)

  • Scott W. Lowe

    (Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

  • Michele A. Cleary

    (Rosetta Inpharmatics, 401 Terry Avenue N., Seattle, Washington 98109, USA)

  • Gregory J. Hannon

    (Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA)

Abstract

MicroRNAs in cancer The tumour suppressor p53 is the most commonly mutated gene in human cancers, and probably nearly all tumours have a lesion somewhere in this pathway. The p53 network is activated in response to numerous insults to restrain inappropriate cell proliferation either via growth arrest or cell death. MicroRNAs (miRNAs) are increasingly recognized for playing important parts in cancer, but little is know about how miRNA expression is regulated. Now a miRNA component of the p53 tumour suppressor network has been identified: p53 directly activates the transcription of the miR-34 family of miRNAs, which themselves suppress cell proliferation. Though dozens of p53 targets are known in mammals, miR-34 is unusual in that it is also present in Drosophila and the nematode worm C. elegans. This suggests that the link between p53 and miR-34 may have arisen early in the evolution of the p53 network.

Suggested Citation

  • Lin He & Xingyue He & Lee P. Lim & Elisa de Stanchina & Zhenyu Xuan & Yu Liang & Wen Xue & Lars Zender & Jill Magnus & Dana Ridzon & Aimee L. Jackson & Peter S. Linsley & Caifu Chen & Scott W. Lowe & , 2007. "A microRNA component of the p53 tumour suppressor network," Nature, Nature, vol. 447(7148), pages 1130-1134, June.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7148:d:10.1038_nature05939
    DOI: 10.1038/nature05939
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    Cited by:

    1. Ya′nan Zhu & Jing He & Jiawen Wang & Wei Guo & Hongran Liu & Zhuoran Song & Le Kang, 2024. "Parental experiences orchestrate locust egg hatching synchrony by regulating nuclear export of precursor miRNA," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. San-Nung Chen & Renin Chang & Li-Te Lin & Chyi-Uei Chern & Hsiao-Wen Tsai & Zhi-Hong Wen & Yi-Han Li & Chia-Jung Li & Kuan-Hao Tsui, 2019. "MicroRNA in Ovarian Cancer: Biology, Pathogenesis, and Therapeutic Opportunities," IJERPH, MDPI, vol. 16(9), pages 1-14, April.
    3. Johanna Zerbib & Marica Rosaria Ippolito & Yonatan Eliezer & Giuseppina Feudis & Eli Reuveni & Anouk Savir Kadmon & Sara Martin & Sonia Viganò & Gil Leor & James Berstler & Julia Muenzner & Michael Mü, 2024. "Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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