IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-10202-3.html
   My bibliography  Save this article

6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda

Author

Listed:
  • Shunmin He

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Guoqiang Zhang

    (Chinese Academy of Sciences)

  • Jiajia Wang

    (Chinese Academy of Sciences)

  • Yajie Gao

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Ruidi Sun

    (Chinese Academy of Sciences
    Anhui Agricultural University)

  • Zhijie Cao

    (Chinese Academy of Sciences)

  • Zhenping Chen

    (Chinese Academy of Sciences)

  • Xiudeng Zheng

    (Chinese Academy of Sciences)

  • Jiao Yuan

    (Chinese Academy of Sciences)

  • Yuewan Luo

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Xiaona Wang

    (Chinese Academy of Sciences)

  • Wenxin Zhang

    (Chinese Academy of Sciences
    Anhui Agricultural University)

  • Peng Zhang

    (Chinese Academy of Sciences)

  • Yi Zhao

    (Chinese Academy of Sciences)

  • Chuan He

    (The University of Chicago)

  • Yi Tao

    (Chinese Academy of Sciences)

  • Qinmiao Sun

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Dahua Chen

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

Abstract

A long-standing question in the field of embryogenesis is how the zygotic genome is precisely activated by maternal factors, allowing normal early embryonic development. We have previously shown that N6-methyladenine (6mA) DNA modification is highly dynamic in early Drosophila embryos and forms an epigenetic mark. However, little is known about how 6mA-formed epigenetic information is decoded. Here we report that the Fox-family protein Jumu binds 6mA-marked DNA and acts as a maternal factor to regulate the maternal-to-zygotic transition. We find that zelda encoding the pioneer factor Zelda is marked by 6mA. Our genetic assays suggest that Jumu controls the proper zygotic genome activation (ZGA) in early embryos, at least in part, by regulating zelda expression. Thus, our findings not only support that the 6mA-formed epigenetic marks can be read by specific transcription factors, but also uncover a mechanism by which the Jumu regulates ZGA partially through Zelda in early embryos.

Suggested Citation

  • Shunmin He & Guoqiang Zhang & Jiajia Wang & Yajie Gao & Ruidi Sun & Zhijie Cao & Zhenping Chen & Xiudeng Zheng & Jiao Yuan & Yuewan Luo & Xiaona Wang & Wenxin Zhang & Peng Zhang & Yi Zhao & Chuan He &, 2019. "6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10202-3
    DOI: 10.1038/s41467-019-10202-3
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-10202-3
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-10202-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ya′nan Zhu & Jing He & Jiawen Wang & Wei Guo & Hongran Liu & Zhuoran Song & Le Kang, 2024. "Parental experiences orchestrate locust egg hatching synchrony by regulating nuclear export of precursor miRNA," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Guoqiang Zhang & Yongru Xu & Xiaona Wang & Yuanxiang Zhu & Liangliang Wang & Wenxin Zhang & Yiru Wang & Yajie Gao & Xuna Wu & Ying Cheng & Qinmiao Sun & Dahua Chen, 2022. "Dynamic FMR1 granule phase switch instructed by m6A modification contributes to maternal RNA decay," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10202-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.