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6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda

Author

Listed:
  • Shunmin He

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Guoqiang Zhang

    (Chinese Academy of Sciences)

  • Jiajia Wang

    (Chinese Academy of Sciences)

  • Yajie Gao

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Ruidi Sun

    (Chinese Academy of Sciences
    Anhui Agricultural University)

  • Zhijie Cao

    (Chinese Academy of Sciences)

  • Zhenping Chen

    (Chinese Academy of Sciences)

  • Xiudeng Zheng

    (Chinese Academy of Sciences)

  • Jiao Yuan

    (Chinese Academy of Sciences)

  • Yuewan Luo

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Xiaona Wang

    (Chinese Academy of Sciences)

  • Wenxin Zhang

    (Chinese Academy of Sciences
    Anhui Agricultural University)

  • Peng Zhang

    (Chinese Academy of Sciences)

  • Yi Zhao

    (Chinese Academy of Sciences)

  • Chuan He

    (The University of Chicago)

  • Yi Tao

    (Chinese Academy of Sciences)

  • Qinmiao Sun

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Dahua Chen

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

Abstract

A long-standing question in the field of embryogenesis is how the zygotic genome is precisely activated by maternal factors, allowing normal early embryonic development. We have previously shown that N6-methyladenine (6mA) DNA modification is highly dynamic in early Drosophila embryos and forms an epigenetic mark. However, little is known about how 6mA-formed epigenetic information is decoded. Here we report that the Fox-family protein Jumu binds 6mA-marked DNA and acts as a maternal factor to regulate the maternal-to-zygotic transition. We find that zelda encoding the pioneer factor Zelda is marked by 6mA. Our genetic assays suggest that Jumu controls the proper zygotic genome activation (ZGA) in early embryos, at least in part, by regulating zelda expression. Thus, our findings not only support that the 6mA-formed epigenetic marks can be read by specific transcription factors, but also uncover a mechanism by which the Jumu regulates ZGA partially through Zelda in early embryos.

Suggested Citation

  • Shunmin He & Guoqiang Zhang & Jiajia Wang & Yajie Gao & Ruidi Sun & Zhijie Cao & Zhenping Chen & Xiudeng Zheng & Jiao Yuan & Yuewan Luo & Xiaona Wang & Wenxin Zhang & Peng Zhang & Yi Zhao & Chuan He &, 2019. "6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10202-3
    DOI: 10.1038/s41467-019-10202-3
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    Cited by:

    1. Guoqiang Zhang & Yongru Xu & Xiaona Wang & Yuanxiang Zhu & Liangliang Wang & Wenxin Zhang & Yiru Wang & Yajie Gao & Xuna Wu & Ying Cheng & Qinmiao Sun & Dahua Chen, 2022. "Dynamic FMR1 granule phase switch instructed by m6A modification contributes to maternal RNA decay," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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