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Two-dimensional coordination risedronate-manganese nanobelts as adjuvant for cancer radiotherapy and immunotherapy

Author

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  • Zhusheng Huang

    (Nanjing University of Posts and Telecommunications
    Nanjing University of Posts and Telecommunications
    University of Macau
    University of Macau)

  • Shiqian Huang

    (Nanjing University of Posts and Telecommunications)

  • Simin Song

    (Nanjing University of Posts and Telecommunications)

  • Yankui Ding

    (Nanjing University of Posts and Telecommunications)

  • Hao Zhou

    (Nanjing University of Posts and Telecommunications)

  • Shaoyin Zhang

    (Nanjing University of Posts and Telecommunications)

  • Lixing Weng

    (Nanjing University of Posts and Telecommunications
    Nanjing University of Posts and Telecommunications)

  • Ying Zhang

    (Nanjing University of Posts and Telecommunications
    Nanjing University of Posts and Telecommunications)

  • Yiqiao Hu

    (Nanjing University)

  • Ahu Yuan

    (Nanjing University)

  • Yunlu Dai

    (University of Macau
    University of Macau)

  • Zhimin Luo

    (Nanjing University of Posts and Telecommunications
    Nanjing University of Posts and Telecommunications)

  • Lianhui Wang

    (Nanjing University of Posts and Telecommunications
    Nanjing University of Posts and Telecommunications)

Abstract

The irradiated tumor itself represents an opportunity to establish endogenous in situ vaccines. However, such in situ cancer vaccination (ISCV) triggered by radiation therapy (RT) alone is very weak and hardly elicits systemic anticancer immunity. In this study, we develop two-dimensional risedronate-manganese nanobelts (RMn-NBs) as an adjuvant for RT to address this issue. RMn-NBs exhibit good T2 magnetic resonance imaging performance and enhanced Fenton-like catalytic activity, which induces immunogenic cell death. RMn-NBs can inhibit the HIF-1α/VEGF axis to empower RT and synchronously activate the cGAS/STING pathway for promoting the secretion of type I interferon, thereby boosting RT-triggered ISCV and immune checkpoint blockade therapy against primary and metastatic tumors. RMn-NBs as a nano-adjuvant for RT show good biocompatibility and therapeutic efficacy, presenting a promising prospect for cancer radiotherapy and immunotherapy.

Suggested Citation

  • Zhusheng Huang & Shiqian Huang & Simin Song & Yankui Ding & Hao Zhou & Shaoyin Zhang & Lixing Weng & Ying Zhang & Yiqiao Hu & Ahu Yuan & Yunlu Dai & Zhimin Luo & Lianhui Wang, 2024. "Two-dimensional coordination risedronate-manganese nanobelts as adjuvant for cancer radiotherapy and immunotherapy," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53084-w
    DOI: 10.1038/s41467-024-53084-w
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    References listed on IDEAS

    as
    1. Zhusheng Huang & Rong Gu & Shiqian Huang & Qian Chen & Jing Yan & Xiaoya Cui & Haojie Jiang & Dan Yao & Chuang Shen & Jiayue Su & Tao Liu & Jinhui Wu & Zhimin Luo & Yiqiao Hu & Ahu Yuan, 2024. "Chiral coordination polymer nanowires boost radiation-induced in situ tumor vaccination," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Zhusheng Huang & Yuxiang Wang & Dan Yao & Jinhui Wu & Yiqiao Hu & Ahu Yuan, 2021. "Nanoscale coordination polymers induce immunogenic cell death by amplifying radiation therapy mediated oxidative stress," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    3. Ying Zhang & Raghava N. Sriramaneni & Paul A. Clark & Justin C. Jagodinsky & Mingzhou Ye & Wonjong Jin & Yuyuan Wang & Amber Bates & Caroline P. Kerr & Trang Le & Raad Allawi & Xiuxiu Wang & Ruosen Xi, 2022. "Multifunctional nanoparticle potentiates the in situ vaccination effect of radiation therapy and enhances response to immune checkpoint blockade," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
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