Cascaded immunotherapy with implantable dual-drug depots sequentially releasing STING agonists and apoptosis inducers
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DOI: 10.1038/s41467-025-56407-7
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- Joshi M. Ramanjulu & G. Scott Pesiridis & Jingsong Yang & Nestor Concha & Robert Singhaus & Shu-Yun Zhang & Jean-Luc Tran & Patrick Moore & Stephanie Lehmann & H. Christian Eberl & Marcel Muelbaier & , 2018. "Design of amidobenzimidazole STING receptor agonists with systemic activity," Nature, Nature, vol. 564(7736), pages 439-443, December.
- Keisuke Yamamoto & Anthony Venida & Julian Yano & Douglas E. Biancur & Miwako Kakiuchi & Suprit Gupta & Albert S. W. Sohn & Subhadip Mukhopadhyay & Elaine Y. Lin & Seth J. Parker & Robert S. Banh & Jo, 2020. "Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I," Nature, Nature, vol. 581(7806), pages 100-105, May.
- Jing Liu & Zhihao Zhao & Nasha Qiu & Quan Zhou & Guowei Wang & Haiping Jiang & Ying Piao & Zhuxian Zhou & Jianbin Tang & Youqing Shen, 2021. "Co-delivery of IOX1 and doxorubicin for antibody-independent cancer chemo-immunotherapy," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
- Conggang Zhang & Guijun Shang & Xiang Gui & Xuewu Zhang & Xiao-chen Bai & Zhijian J. Chen, 2019. "Structural basis of STING binding with and phosphorylation by TBK1," Nature, Nature, vol. 567(7748), pages 394-398, March.
- Delphine Goubau & Martin Schlee & Safia Deddouche & Andrea J. Pruijssers & Thomas Zillinger & Marion Goldeck & Christine Schuberth & Annemarthe G. Van der Veen & Tsutomu Fujimura & Jan Rehwinkel & Jas, 2014. "Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates," Nature, Nature, vol. 514(7522), pages 372-375, October.
- Zhusheng Huang & Yuxiang Wang & Dan Yao & Jinhui Wu & Yiqiao Hu & Ahu Yuan, 2021. "Nanoscale coordination polymers induce immunogenic cell death by amplifying radiation therapy mediated oxidative stress," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
- Tian-Chen Xiong & Ming-Cong Wei & Fang-Xu Li & Miao Shi & Hu Gan & Zhen Tang & Hong-Peng Dong & Tianzi Liuyu & Pu Gao & Bo Zhong & Zhi-Dong Zhang & Dandan Lin, 2022. "The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
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