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The matrisome landscape controlling in vivo germ cell fates

Author

Listed:
  • Aqilah Amran

    (Lund University
    Lund University
    Lund University
    Monash University)

  • Lara Pigatto

    (Lund University
    Lund University
    Lund University
    Monash University)

  • Johanna Farley

    (Lund University
    Lund University
    Lund University)

  • Rasoul Godini

    (Monash University)

  • Roger Pocock

    (Monash University)

  • Sandeep Gopal

    (Lund University
    Lund University
    Lund University
    Monash University)

Abstract

The developmental fate of cells is regulated by intrinsic factors and the extracellular environment. The extracellular matrix (matrisome) delivers chemical and mechanical cues that can modify cellular development. However, comprehensive understanding of how matrisome factors control cells in vivo is lacking. Here we show that specific matrisome factors act individually and collectively to control germ cell development. Surveying development of undifferentiated germline stem cells through to mature oocytes in the Caenorhabditis elegans germ line enabled holistic functional analysis of 443 conserved matrisome-coding genes. Using high-content imaging, 3D reconstruction, and cell behavior analysis, we identify 321 matrisome genes that impact germ cell development, the majority of which (>80%) are undescribed. Our analysis identifies key matrisome networks acting autonomously and non-autonomously to coordinate germ cell behavior. Further, our results demonstrate that germ cell development requires continual remodeling of the matrisome landscape. Together, this study provides a comprehensive platform for deciphering how extracellular signaling controls cellular development and anticipate this will establish new opportunities for manipulating cell fates.

Suggested Citation

  • Aqilah Amran & Lara Pigatto & Johanna Farley & Rasoul Godini & Roger Pocock & Sandeep Gopal, 2024. "The matrisome landscape controlling in vivo germ cell fates," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48283-4
    DOI: 10.1038/s41467-024-48283-4
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    2. Leland Wilkinson, 2011. "ggplot2: Elegant Graphics for Data Analysis by WICKHAM, H," Biometrics, The International Biometric Society, vol. 67(2), pages 678-679, June.
    3. Sandeep Gopal & Aqilah Amran & Andre Elton & Leelee Ng & Roger Pocock, 2021. "A somatic proteoglycan controls Notch-directed germ cell fate," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
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