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A somatic proteoglycan controls Notch-directed germ cell fate

Author

Listed:
  • Sandeep Gopal

    (Monash University)

  • Aqilah Amran

    (Monash University)

  • Andre Elton

    (Monash University)

  • Leelee Ng

    (Monash University)

  • Roger Pocock

    (Monash University)

Abstract

Communication between the soma and germline optimizes germ cell fate programs. Notch receptors are key determinants of germ cell fate but how somatic signals direct Notch-dependent germ cell behavior is undefined. Here we demonstrate that SDN-1 (syndecan-1), a somatic transmembrane proteoglycan, controls expression of the GLP-1 (germline proliferation-1) Notch receptor in the Caenorhabditis elegans germline. We find that SDN-1 control of a somatic TRP calcium channel governs calcium-dependent binding of an AP-2 transcription factor (APTF-2) to the glp-1 promoter. Hence, SDN-1 signaling promotes GLP-1 expression and mitotic germ cell fate. Together, these data reveal SDN-1 as a putative communication nexus between the germline and its somatic environment to control germ cell fate decisions.

Suggested Citation

  • Sandeep Gopal & Aqilah Amran & Andre Elton & Leelee Ng & Roger Pocock, 2021. "A somatic proteoglycan controls Notch-directed germ cell fate," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27039-4
    DOI: 10.1038/s41467-021-27039-4
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    References listed on IDEAS

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    1. Daniel D. Shaye & Iva Greenwald, 2002. "Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans," Nature, Nature, vol. 420(6916), pages 686-690, December.
    2. Fumio Nakaki & Katsuhiko Hayashi & Hiroshi Ohta & Kazuki Kurimoto & Yukihiro Yabuta & Mitinori Saitou, 2013. "Induction of mouse germ-cell fate by transcription factors in vitro," Nature, Nature, vol. 501(7466), pages 222-226, September.
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    Cited by:

    1. Sarah R. Fausett & Asma Sandjak & Bénédicte Billard & Christian Braendle, 2023. "Higher-order epistasis shapes natural variation in germ stem cell niche activity," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Aqilah Amran & Lara Pigatto & Johanna Farley & Rasoul Godini & Roger Pocock & Sandeep Gopal, 2024. "The matrisome landscape controlling in vivo germ cell fates," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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