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The genomic evolutionary dynamics and global circulation patterns of respiratory syncytial virus

Author

Listed:
  • Annefleur C. Langedijk

    (University Medical Centre Utrecht)

  • Bram Vrancken

    (Laboratory of Clinical and Epidemiological Virology
    Université Libre de Bruxelles)

  • Robert Jan Lebbink

    (University Medical Center Utrecht)

  • Deidre Wilkins

    (BioPharmaceuticals R&D, AstraZeneca)

  • Elizabeth J. Kelly

    (BioPharmaceuticals R&D, AstraZeneca)

  • Eugenio Baraldi

    (University Hospital of Padova
    ReSViNET Foundation
    Institute of Pediatric Research “Città della Speranza”)

  • Abiel Homero Mascareñas de Los Santos

    (Jose Eluterio Gonzalez Hospital Universitario)

  • Daria M. Danilenko

    (Smorodintsev Research Institute of Influenza)

  • Eun Hwa Choi

    (Seoul National University Children’s Hospital)

  • María Angélica Palomino

    (Universidad de Chile)

  • Hsin Chi

    (MacKay Children’s Hospital)

  • Christian Keller

    (University Hospital Giessen and Marburg)

  • Robert Cohen

    (Université Paris XII)

  • Jesse Papenburg

    (McGill University Health Centre)

  • Jeffrey Pernica

    (McMaster University)

  • Anne Greenough

    (ReSViNET Foundation
    King’s College London)

  • Peter Richmond

    (University of Western Australia)

  • Federico Martinón-Torres

    (ReSViNET Foundation
    Hospital Clínico Universitario de Santiago)

  • Terho Heikkinen

    (ReSViNET Foundation
    University of Turku and Turku University Hospital)

  • Renato T. Stein

    (ReSViNET Foundation
    Pontificia Universidade Catolica de Rio Grande do Sul)

  • Mitsuaki Hosoya

    (Fukushima Medical University School of Medicine)

  • Marta C. Nunes

    (ReSViNET Foundation
    University of the Witwatersrand
    University of the Witwatersrand)

  • Charl Verwey

    (University of the Witwatersrand
    ENS de Lyon)

  • Anouk Evers

    (University Medical Center Utrecht)

  • Leyla Kragten-Tabatabaie

    (ReSViNET Foundation)

  • Marc A. Suchard

    (University of California
    University of California
    University of California)

  • Sergei L. Kosakovsky Pond

    (Temple University)

  • Chiara Poletto

    (Institut Pierre Louis d’Epidémiologie et de Santé Publique IPLESP)

  • Vittoria Colizza

    (Institut Pierre Louis d’Epidémiologie et de Santé Publique IPLESP)

  • Philippe Lemey

    (Laboratory of Clinical and Epidemiological Virology)

  • Louis J. Bont

    (University Medical Centre Utrecht
    ReSViNET Foundation)

Abstract

Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infection in young children and the second leading cause of infant death worldwide. While global circulation has been extensively studied for respiratory viruses such as seasonal influenza, and more recently also in great detail for SARS-CoV-2, a lack of global multi-annual sampling of complete RSV genomes limits our understanding of RSV molecular epidemiology. Here, we capitalise on the genomic surveillance by the INFORM-RSV study and apply phylodynamic approaches to uncover how selection and neutral epidemiological processes shape RSV diversity. Using complete viral genome sequences, we show similar patterns of site-specific diversifying selection among RSVA and RSVB and recover the imprint of non-neutral epidemic processes on their genealogies. Using a phylogeographic approach, we provide evidence for air travel governing the global patterns of RSVA and RSVB spread, which results in a considerable degree of phylogenetic mixing across countries. Our findings highlight the potential of systematic global RSV genomic surveillance for transforming our understanding of global RSV spread.

Suggested Citation

  • Annefleur C. Langedijk & Bram Vrancken & Robert Jan Lebbink & Deidre Wilkins & Elizabeth J. Kelly & Eugenio Baraldi & Abiel Homero Mascareñas de Los Santos & Daria M. Danilenko & Eun Hwa Choi & María , 2024. "The genomic evolutionary dynamics and global circulation patterns of respiratory syncytial virus," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47118-6
    DOI: 10.1038/s41467-024-47118-6
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    References listed on IDEAS

    as
    1. Alexei J Drummond & Simon Y W Ho & Matthew J Phillips & Andrew Rambaut, 2006. "Relaxed Phylogenetics and Dating with Confidence," PLOS Biology, Public Library of Science, vol. 4(5), pages 1-1, March.
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