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Artificial cells for in vivo biomedical applications through red blood cell biomimicry

Author

Listed:
  • Jorik Waeterschoot

    (KU Leuven)

  • Willemien Gosselé

    (KU Leuven)

  • Špela Lemež

    (KU Leuven)

  • Xavier Casadevall i Solvas

    (KU Leuven)

Abstract

Recent research in artificial cell production holds promise for the development of delivery agents with therapeutic effects akin to real cells. To succeed in these applications, these systems need to survive the circulatory conditions. In this review we present strategies that, inspired by the endurance of red blood cells, have enhanced the viability of large, cell-like vehicles for in vivo therapeutic use, particularly focusing on giant unilamellar vesicles. Insights from red blood cells can guide modifications that could transform these platforms into advanced drug delivery vehicles, showcasing biomimicry’s potential in shaping the future of therapeutic applications.

Suggested Citation

  • Jorik Waeterschoot & Willemien Gosselé & Špela Lemež & Xavier Casadevall i Solvas, 2024. "Artificial cells for in vivo biomedical applications through red blood cell biomimicry," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46732-8
    DOI: 10.1038/s41467-024-46732-8
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    References listed on IDEAS

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    1. Nishkantha Arulkumaran & Mervyn Singer & Stefan Howorka & Jonathan R. Burns, 2023. "Creating complex protocells and prototissues using simple DNA building blocks," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Thomas Litschel & Charlotte F. Kelley & Danielle Holz & Maral Adeli Koudehi & Sven K. Vogel & Laura Burbaum & Naoko Mizuno & Dimitrios Vavylonis & Petra Schwille, 2021. "Reconstitution of contractile actomyosin rings in vesicles," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    3. Xuqing Zhang & Mengyao Luo & Shamael R. Dastagir & Mellissa Nixon & Annie Khamhoung & Andrea Schmidt & Albert Lee & Naren Subbiah & Douglas C. McLaughlin & Christopher L. Moore & Mary Gribble & Nichol, 2021. "Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    4. Siddharth Deshpande & Yaron Caspi & Anna E. C. Meijering & Cees Dekker, 2016. "Octanol-assisted liposome assembly on chip," Nature Communications, Nature, vol. 7(1), pages 1-9, April.
    5. Rafi Chapanian & David H. Kwan & Iren Constantinescu & Fathima A. Shaikh & Nicholas A..A. Rossi & Stephen G Withers & Jayachandran N Kizhakkedathu, 2014. "Enhancement of biological reactions on cell surfaces via macromolecular crowding," Nature Communications, Nature, vol. 5(1), pages 1-12, December.
    6. Qingchuan Li & Shubin Li & Xiangxiang Zhang & Weili Xu & Xiaojun Han, 2020. "Programmed magnetic manipulation of vesicles into spatially coded prototissue architectures arrays," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
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