IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-42138-0.html
   My bibliography  Save this article

Subventricular zone cytogenesis provides trophic support for neural repair in a mouse model of stroke

Author

Listed:
  • Michael R. Williamson

    (University of Texas at Austin
    Baylor College of Medicine)

  • Stephanie P. Le

    (University of Texas at Austin)

  • Ronald L. Franzen

    (University of Texas at Austin
    Baylor College of Medicine)

  • Nicole A. Donlan

    (University of Texas at Austin)

  • Jill L. Rosow

    (University of Texas at Austin)

  • Mathilda S. Nicot-Cartsonis

    (University of Texas Medical Branch at Galveston)

  • Alexis Cervantes

    (Baylor College of Medicine
    Baylor College of Medicine)

  • Benjamin Deneen

    (Baylor College of Medicine
    Baylor College of Medicine)

  • Andrew K. Dunn

    (University of Texas at Austin
    University of Texas at Austin)

  • Theresa A. Jones

    (University of Texas at Austin
    University of Texas at Austin)

  • Michael R. Drew

    (University of Texas at Austin
    University of Texas at Austin)

Abstract

Stroke enhances proliferation of neural precursor cells within the subventricular zone (SVZ) and induces ectopic migration of newborn cells towards the site of injury. Here, we characterize the identity of cells arising from the SVZ after stroke and uncover a mechanism through which they facilitate neural repair and functional recovery. With genetic lineage tracing, we show that SVZ-derived cells that migrate towards cortical photothrombotic stroke in mice are predominantly undifferentiated precursors. We find that ablation of neural precursor cells or conditional knockout of VEGF impairs neuronal and vascular reparative responses and worsens recovery. Replacement of VEGF is sufficient to induce neural repair and recovery. We also provide evidence that CXCL12 from peri-infarct vasculature signals to CXCR4-expressing cells arising from the SVZ to direct their ectopic migration. These results support a model in which vasculature surrounding the site of injury attracts cells from the SVZ, and these cells subsequently provide trophic support that drives neural repair and recovery.

Suggested Citation

  • Michael R. Williamson & Stephanie P. Le & Ronald L. Franzen & Nicole A. Donlan & Jill L. Rosow & Mathilda S. Nicot-Cartsonis & Alexis Cervantes & Benjamin Deneen & Andrew K. Dunn & Theresa A. Jones & , 2023. "Subventricular zone cytogenesis provides trophic support for neural repair in a mouse model of stroke," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42138-0
    DOI: 10.1038/s41467-023-42138-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-42138-0
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-023-42138-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Moises Freitas-Andrade & Cesar H. Comin & Peter Dyken & Julie Ouellette & Joanna Raman-Nair & Nicole Blakeley & Qing Yan Liu & Sonia Leclerc & Youlian Pan & Ziying Liu & Micaël Carrier & Karan Thakur , 2023. "Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular maturation," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    2. Michael Lattke & Robert Goldstone & James K. Ellis & Stefan Boeing & Jerónimo Jurado-Arjona & Nicolás Marichal & James I. MacRae & Benedikt Berninger & Francois Guillemot, 2021. "Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    3. Nader Sanai & Anthony D. Tramontin & Alfredo Quiñones-Hinojosa & Nicholas M. Barbaro & Nalin Gupta & Sandeep Kunwar & Michael T. Lawton & Michael W. McDermott & Andrew T. Parsa & José Manuel-García Ve, 2004. "Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration," Nature, Nature, vol. 427(6976), pages 740-744, February.
    4. Stefano Pluchino & Lucia Zanotti & Barbara Rossi & Elena Brambilla & Linda Ottoboni & Giuliana Salani & Marianna Martinello & Alessandro Cattalini & Alessandra Bergami & Roberto Furlan & Giancarlo Com, 2005. "Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism," Nature, Nature, vol. 436(7048), pages 266-271, July.
    5. Kelly A. Tennant & Stephanie L. Taylor & Emily R. White & Craig E. Brown, 2017. "Optogenetic rewiring of thalamocortical circuits to restore function in the stroke injured brain," Nature Communications, Nature, vol. 8(1), pages 1-14, August.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Yi Huang & Anyongqi Wang & Wenjiang Zhou & Baoguo Li & Linshan Zhang & Agata M. Rudolf & Zengguang Jin & Catherine Hambly & Guanlin Wang & John R. Speakman, 2024. "Maternal dietary fat during lactation shapes single nucleus transcriptomic profile of postnatal offspring hypothalamus in a sexually dimorphic manner in mice," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Erica Butti & Stefano Cattaneo & Marco Bacigaluppi & Marco Cambiaghi & Giulia Maria Scotti & Elena Brambilla & Francesca Ruffini & Giacomo Sferruzza & Maddalena Ripamonti & Fabio Simeoni & Laura Cacci, 2022. "Neural precursor cells tune striatal connectivity through the release of IGFBPL1," Nature Communications, Nature, vol. 13(1), pages 1-23, December.
    3. Mohamad Motaharinia & Kim Gerrow & Roobina Boghozian & Emily White & Sun-Eui Choi & Kerry R. Delaney & Craig E. Brown, 2021. "Longitudinal functional imaging of VIP interneurons reveals sup-population specific effects of stroke that are rescued with chemogenetic therapy," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    4. Ruohan Wang & Yumin Zheng & Zijian Zhang & Kailu Song & Erxi Wu & Xiaopeng Zhu & Tao P. Wu & Jun Ding, 2024. "MATES: a deep learning-based model for locus-specific quantification of transposable elements in single cell," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42138-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.