IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-46019-y.html
   My bibliography  Save this article

Metabolomic profiles of sleep-disordered breathing are associated with hypertension and diabetes mellitus development

Author

Listed:
  • Ying Zhang

    (Brigham and Women’s Hospital)

  • Bing Yu

    (The University of Texas Health Science Center at Houston)

  • Qibin Qi

    (Albert Einstein College of Medicine, Bronx)

  • Ali Azarbarzin

    (Brigham & Women’s Hospital & Harvard Medical School)

  • Han Chen

    (The University of Texas Health Science Center at Houston)

  • Neomi A. Shah

    (Icahn School of Medicine at Mount Sinai)

  • Alberto R. Ramos

    (University of Miami Miller School of Medicine)

  • Phyllis C. Zee

    (Northwestern University)

  • Jianwen Cai

    (University of North Carolina at Chapel Hill)

  • Martha L. Daviglus

    (Northwestern University Feinberg School of Medicine)

  • Eric Boerwinkle

    (The University of Texas Health Science Center at Houston)

  • Robert Kaplan

    (Albert Einstein College of Medicine, Bronx
    Fred Hutchinson Cancer Research Center)

  • Peter Y. Liu

    (The Lundquist Institute at Harbor-UCLA Medical Center)

  • Susan Redline

    (Brigham & Women’s Hospital & Harvard Medical School)

  • Tamar Sofer

    (Brigham & Women’s Hospital & Harvard Medical School
    Harvard T.H. Chan School of Public Health
    Beth Israel Deaconess Medical Center)

Abstract

Sleep-disordered breathing (SDB) is a prevalent disorder characterized by recurrent episodic upper airway obstruction. Using data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), we apply principal component analysis (PCA) to seven SDB-related measures. We estimate the associations of the top two SDB PCs with serum levels of 617 metabolites, in both single-metabolite analysis, and a joint penalized regression analysis. The discovery analysis includes 3299 individuals, with validation in a separate dataset of 1522 individuals. Five metabolite associations with SDB PCs are discovered and replicated. SDB PC1, characterized by frequent respiratory events common in older and male adults, is associated with pregnanolone and progesterone-related sulfated metabolites. SDB PC2, characterized by short respiratory event length and self-reported restless sleep, enriched in young adults, is associated with sphingomyelins. Metabolite risk scores (MRSs), representing metabolite signatures associated with the two SDB PCs, are associated with 6-year incident hypertension and diabetes. These MRSs have the potential to serve as biomarkers for SDB, guiding risk stratification and treatment decisions.

Suggested Citation

  • Ying Zhang & Bing Yu & Qibin Qi & Ali Azarbarzin & Han Chen & Neomi A. Shah & Alberto R. Ramos & Phyllis C. Zee & Jianwen Cai & Martha L. Daviglus & Eric Boerwinkle & Robert Kaplan & Peter Y. Liu & Su, 2024. "Metabolomic profiles of sleep-disordered breathing are associated with hypertension and diabetes mellitus development," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46019-y
    DOI: 10.1038/s41467-024-46019-y
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-46019-y
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-46019-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Lumley, Thomas, 2004. "Analysis of Complex Survey Samples," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 9(i08).
    2. Friedman, Jerome H. & Hastie, Trevor & Tibshirani, Rob, 2010. "Regularization Paths for Generalized Linear Models via Coordinate Descent," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 33(i01).
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Christian A. Maino Vieytes & Ruoqing Zhu & Francesca Gany & Amirah Burton-Obanla & Anna E. Arthur, 2022. "Empirical Dietary Patterns Associated with Food Insecurity in U.S. Cancer Survivors: NHANES 1999–2018," IJERPH, MDPI, vol. 19(21), pages 1-21, October.
    2. Tutz, Gerhard & Pößnecker, Wolfgang & Uhlmann, Lorenz, 2015. "Variable selection in general multinomial logit models," Computational Statistics & Data Analysis, Elsevier, vol. 82(C), pages 207-222.
    3. Ernesto Carrella & Richard M. Bailey & Jens Koed Madsen, 2018. "Indirect inference through prediction," Papers 1807.01579, arXiv.org.
    4. Rui Wang & Naihua Xiu & Kim-Chuan Toh, 2021. "Subspace quadratic regularization method for group sparse multinomial logistic regression," Computational Optimization and Applications, Springer, vol. 79(3), pages 531-559, July.
    5. Mkhadri, Abdallah & Ouhourane, Mohamed, 2013. "An extended variable inclusion and shrinkage algorithm for correlated variables," Computational Statistics & Data Analysis, Elsevier, vol. 57(1), pages 631-644.
    6. Masakazu Higuchi & Mitsuteru Nakamura & Shuji Shinohara & Yasuhiro Omiya & Takeshi Takano & Daisuke Mizuguchi & Noriaki Sonota & Hiroyuki Toda & Taku Saito & Mirai So & Eiji Takayama & Hiroo Terashi &, 2022. "Detection of Major Depressive Disorder Based on a Combination of Voice Features: An Exploratory Approach," IJERPH, MDPI, vol. 19(18), pages 1-13, September.
    7. Susan Athey & Guido W. Imbens & Stefan Wager, 2018. "Approximate residual balancing: debiased inference of average treatment effects in high dimensions," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 80(4), pages 597-623, September.
    8. Vincent, Martin & Hansen, Niels Richard, 2014. "Sparse group lasso and high dimensional multinomial classification," Computational Statistics & Data Analysis, Elsevier, vol. 71(C), pages 771-786.
    9. Maciej Berk{e}sewicz & Herman Cherniaiev & Robert Pater, 2021. "Estimating the number of entities with vacancies using administrative and online data," Papers 2106.03263, arXiv.org.
    10. Chen, Le-Yu & Lee, Sokbae, 2018. "Best subset binary prediction," Journal of Econometrics, Elsevier, vol. 206(1), pages 39-56.
    11. Perrot-Dockès Marie & Lévy-Leduc Céline & Chiquet Julien & Sansonnet Laure & Brégère Margaux & Étienne Marie-Pierre & Robin Stéphane & Genta-Jouve Grégory, 2018. "A variable selection approach in the multivariate linear model: an application to LC-MS metabolomics data," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 17(5), pages 1-14, October.
    12. Fan, Jianqing & Jiang, Bai & Sun, Qiang, 2022. "Bayesian factor-adjusted sparse regression," Journal of Econometrics, Elsevier, vol. 230(1), pages 3-19.
    13. Chuliá, Helena & Garrón, Ignacio & Uribe, Jorge M., 2024. "Daily growth at risk: Financial or real drivers? The answer is not always the same," International Journal of Forecasting, Elsevier, vol. 40(2), pages 762-776.
    14. Jun Li & Serguei Netessine & Sergei Koulayev, 2018. "Price to Compete … with Many: How to Identify Price Competition in High-Dimensional Space," Management Science, INFORMS, vol. 64(9), pages 4118-4136, September.
    15. Sung Jae Jun & Sokbae Lee, 2024. "Causal Inference Under Outcome-Based Sampling with Monotonicity Assumptions," Journal of Business & Economic Statistics, Taylor & Francis Journals, vol. 42(3), pages 998-1009, July.
    16. Rina Friedberg & Julie Tibshirani & Susan Athey & Stefan Wager, 2018. "Local Linear Forests," Papers 1807.11408, arXiv.org, revised Sep 2020.
    17. Xiangwei Li & Thomas Delerue & Ben Schöttker & Bernd Holleczek & Eva Grill & Annette Peters & Melanie Waldenberger & Barbara Thorand & Hermann Brenner, 2022. "Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    18. Hewamalage, Hansika & Bergmeir, Christoph & Bandara, Kasun, 2021. "Recurrent Neural Networks for Time Series Forecasting: Current status and future directions," International Journal of Forecasting, Elsevier, vol. 37(1), pages 388-427.
    19. Hui Xiao & Yiguo Sun, 2020. "Forecasting the Returns of Cryptocurrency: A Model Averaging Approach," JRFM, MDPI, vol. 13(11), pages 1-15, November.
    20. Christopher J Greenwood & George J Youssef & Primrose Letcher & Jacqui A Macdonald & Lauryn J Hagg & Ann Sanson & Jenn Mcintosh & Delyse M Hutchinson & John W Toumbourou & Matthew Fuller-Tyszkiewicz &, 2020. "A comparison of penalised regression methods for informing the selection of predictive markers," PLOS ONE, Public Library of Science, vol. 15(11), pages 1-14, November.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46019-y. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.