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Single cell atlas of Xenoturbella bocki highlights limited cell-type complexity

Author

Listed:
  • Helen E. Robertson

    (The University of Chicago
    Institut Pasteur
    University College London)

  • Arnau Sebé-Pedrós

    (Barcelona Institute of Science and Technology (BIST)
    Universitat Pompeu Fabra (UPF)
    ICREA)

  • Baptiste Saudemont

    (Institut Pasteur)

  • Yann Loe-Mie

    (Institut Pasteur)

  • Anne-C. Zakrzewski

    (University College London)

  • Xavier Grau-Bové

    (Barcelona Institute of Science and Technology (BIST))

  • Marie-Pierre Mailhe

    (Institut Pasteur)

  • Philipp Schiffer

    (University College London
    University of Cologne)

  • Maximilian J. Telford

    (University College London)

  • Heather Marlow

    (The University of Chicago
    Institut Pasteur)

Abstract

Phylogenetic analyses over the last two decades have united a few small, and previously orphan clades, the nematodermatids, acoels and xenoturbelids, into the phylum Xenacoelomorpha. Some phylogenetic analyses support a sister relationship between Xenacoelomorpha and Ambulacraria (Xenambulacraria), while others suggest that Xenacoelomorpha may be sister to the rest of the Bilateria (Nephrozoa). An understanding of the cell type complements of Xenacoelomorphs is essential to assessing these alternatives as well as to our broader understanding of bilaterian cell type evolution. Employing whole organism single-cell RNA-seq in the marine xenacoelomorph worm Xenoturbella bocki, we show that Xenambulacrarian nerve nets share regulatory features and a peptidergic identity with those found in cnidarians and protostomes and more broadly share muscle and gland cell similarities with other metazoans. Taken together, these data are consistent with broad homologies of animal gland, muscle, and neurons as well as more specific affinities between Xenoturbella and acoel gut and epidermal tissues, consistent with the monophyly of Xenacoelomorpha.

Suggested Citation

  • Helen E. Robertson & Arnau Sebé-Pedrós & Baptiste Saudemont & Yann Loe-Mie & Anne-C. Zakrzewski & Xavier Grau-Bové & Marie-Pierre Mailhe & Philipp Schiffer & Maximilian J. Telford & Heather Marlow, 2024. "Single cell atlas of Xenoturbella bocki highlights limited cell-type complexity," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45956-y
    DOI: 10.1038/s41467-024-45956-y
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    References listed on IDEAS

    as
    1. Greg W. Rouse & Nerida G. Wilson & Jose I. Carvajal & Robert C. Vrijenhoek, 2016. "New deep-sea species of Xenoturbella and the position of Xenacoelomorpha," Nature, Nature, vol. 530(7588), pages 94-97, February.
    2. Casey W. Dunn & Andreas Hejnol & David Q. Matus & Kevin Pang & William E. Browne & Stephen A. Smith & Elaine Seaver & Greg W. Rouse & Matthias Obst & Gregory D. Edgecombe & Martin V. Sørensen & Steven, 2008. "Broad phylogenomic sampling improves resolution of the animal tree of life," Nature, Nature, vol. 452(7188), pages 745-749, April.
    3. Ryan E. Hulett & Julian O. Kimura & D. Marcela Bolaños & Yi-Jyun Luo & Carlos Rivera-López & Lorenzo Ricci & Mansi Srivastava, 2023. "Acoel single-cell atlas reveals expression dynamics and heterogeneity of adult pluripotent stem cells," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Johanna Taylor Cannon & Bruno Cossermelli Vellutini & Julian Smith & Fredrik Ronquist & Ulf Jondelius & Andreas Hejnol, 2016. "Xenacoelomorpha is the sister group to Nephrozoa," Nature, Nature, vol. 530(7588), pages 89-93, February.
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