IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-45956-y.html
   My bibliography  Save this article

Single cell atlas of Xenoturbella bocki highlights limited cell-type complexity

Author

Listed:
  • Helen E. Robertson

    (The University of Chicago
    Institut Pasteur
    University College London)

  • Arnau Sebé-Pedrós

    (Barcelona Institute of Science and Technology (BIST)
    Universitat Pompeu Fabra (UPF)
    ICREA)

  • Baptiste Saudemont

    (Institut Pasteur)

  • Yann Loe-Mie

    (Institut Pasteur)

  • Anne-C. Zakrzewski

    (University College London)

  • Xavier Grau-Bové

    (Barcelona Institute of Science and Technology (BIST))

  • Marie-Pierre Mailhe

    (Institut Pasteur)

  • Philipp Schiffer

    (University College London
    University of Cologne)

  • Maximilian J. Telford

    (University College London)

  • Heather Marlow

    (The University of Chicago
    Institut Pasteur)

Abstract

Phylogenetic analyses over the last two decades have united a few small, and previously orphan clades, the nematodermatids, acoels and xenoturbelids, into the phylum Xenacoelomorpha. Some phylogenetic analyses support a sister relationship between Xenacoelomorpha and Ambulacraria (Xenambulacraria), while others suggest that Xenacoelomorpha may be sister to the rest of the Bilateria (Nephrozoa). An understanding of the cell type complements of Xenacoelomorphs is essential to assessing these alternatives as well as to our broader understanding of bilaterian cell type evolution. Employing whole organism single-cell RNA-seq in the marine xenacoelomorph worm Xenoturbella bocki, we show that Xenambulacrarian nerve nets share regulatory features and a peptidergic identity with those found in cnidarians and protostomes and more broadly share muscle and gland cell similarities with other metazoans. Taken together, these data are consistent with broad homologies of animal gland, muscle, and neurons as well as more specific affinities between Xenoturbella and acoel gut and epidermal tissues, consistent with the monophyly of Xenacoelomorpha.

Suggested Citation

  • Helen E. Robertson & Arnau Sebé-Pedrós & Baptiste Saudemont & Yann Loe-Mie & Anne-C. Zakrzewski & Xavier Grau-Bové & Marie-Pierre Mailhe & Philipp Schiffer & Maximilian J. Telford & Heather Marlow, 2024. "Single cell atlas of Xenoturbella bocki highlights limited cell-type complexity," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45956-y
    DOI: 10.1038/s41467-024-45956-y
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-45956-y
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-024-45956-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Greg W. Rouse & Nerida G. Wilson & Jose I. Carvajal & Robert C. Vrijenhoek, 2016. "New deep-sea species of Xenoturbella and the position of Xenacoelomorpha," Nature, Nature, vol. 530(7588), pages 94-97, February.
    2. Casey W. Dunn & Andreas Hejnol & David Q. Matus & Kevin Pang & William E. Browne & Stephen A. Smith & Elaine Seaver & Greg W. Rouse & Matthias Obst & Gregory D. Edgecombe & Martin V. Sørensen & Steven, 2008. "Broad phylogenomic sampling improves resolution of the animal tree of life," Nature, Nature, vol. 452(7188), pages 745-749, April.
    3. Ryan E. Hulett & Julian O. Kimura & D. Marcela Bolaños & Yi-Jyun Luo & Carlos Rivera-López & Lorenzo Ricci & Mansi Srivastava, 2023. "Acoel single-cell atlas reveals expression dynamics and heterogeneity of adult pluripotent stem cells," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Johanna Taylor Cannon & Bruno Cossermelli Vellutini & Julian Smith & Fredrik Ronquist & Ulf Jondelius & Andreas Hejnol, 2016. "Xenacoelomorpha is the sister group to Nephrozoa," Nature, Nature, vol. 530(7588), pages 89-93, February.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Matthew Goulty & Gaelle Botton-Amiot & Ezio Rosato & Simon G. Sprecher & Roberto Feuda, 2023. "The monoaminergic system is a bilaterian innovation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Patricia Álvarez-Campos & Helena García-Castro & Elena Emili & Alberto Pérez-Posada & Irene Olmo & Sophie Peron & David A. Salamanca-Díaz & Vincent Mason & Bria Metzger & Alexandra E. Bely & Nathan J., 2024. "Annelid adult cell type diversity and their pluripotent cellular origins," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    3. Toshiyuki Fujita & Naoya Aoki & Chihiro Mori & Koichi J. Homma & Shinji Yamaguchi, 2024. "SoxC and MmpReg promote blastema formation in whole-body regeneration of fragmenting potworms Enchytraeus japonensis," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    4. Maria E Gallegos & Sanjeev Balakrishnan & Priya Chandramouli & Shaily Arora & Aruna Azameera & Anitha Babushekar & Emilee Bargoma & Abdulmalik Bokhari & Siva Kumari Chava & Pranti Das & Meetali Desai , 2012. "The C. elegans Rab Family: Identification, Classification and Toolkit Construction," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-19, November.
    5. Emese Meglécz & Gabriel Nève & Ed Biffin & Michael G Gardner, 2012. "Breakdown of Phylogenetic Signal: A Survey of Microsatellite Densities in 454 Shotgun Sequences from 154 Non Model Eukaryote Species," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-15, July.
    6. Lauren E. Vandepas & Caroline Stefani & Phillip P. Domeier & Nikki Traylor-Knowles & Frederick W. Goetz & William E. Browne & Adam Lacy-Hulbert, 2024. "Extracellular DNA traps in a ctenophore demonstrate immune cell behaviors in a non-bilaterian," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    7. Ryan E. Hulett & Julian O. Kimura & D. Marcela Bolaños & Yi-Jyun Luo & Carlos Rivera-López & Lorenzo Ricci & Mansi Srivastava, 2023. "Acoel single-cell atlas reveals expression dynamics and heterogeneity of adult pluripotent stem cells," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    8. M Antonio Todaro & Tobias Kånneby & Matteo Dal Zotto & Ulf Jondelius, 2011. "Phylogeny of Thaumastodermatidae (Gastrotricha: Macrodasyida) Inferred from Nuclear and Mitochondrial Sequence Data," PLOS ONE, Public Library of Science, vol. 6(3), pages 1-13, March.
    9. Julie D Thompson & Benjamin Linard & Odile Lecompte & Olivier Poch, 2011. "A Comprehensive Benchmark Study of Multiple Sequence Alignment Methods: Current Challenges and Future Perspectives," PLOS ONE, Public Library of Science, vol. 6(3), pages 1-14, March.
    10. Bryan Korithoski & Oralia Kolaczkowski & Krishanu Mukherjee & Reema Kola & Chandra Earl & Bryan Kolaczkowski, 2015. "Evolution of a Novel Antiviral Immune-Signaling Interaction by Partial-Gene Duplication," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-26, September.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45956-y. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.