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The monoaminergic system is a bilaterian innovation

Author

Listed:
  • Matthew Goulty

    (University of Leicester)

  • Gaelle Botton-Amiot

    (University of Fribourg)

  • Ezio Rosato

    (University of Leicester)

  • Simon G. Sprecher

    (University of Fribourg)

  • Roberto Feuda

    (University of Leicester)

Abstract

Monoamines like serotonin, dopamine, and adrenaline/noradrenaline (epinephrine/norepinephrine) act as neuromodulators in the nervous system. They play a role in complex behaviours, cognitive functions such as learning and memory formation, as well as fundamental homeostatic processes such as sleep and feeding. However, the evolutionary origin of the genes required for monoaminergic modulation is uncertain. Using a phylogenomic approach, in this study, we show that most of the genes involved in monoamine production, modulation, and reception originated in the bilaterian stem group. This suggests that the monoaminergic system is a bilaterian novelty and that its evolution may have contributed to the Cambrian diversification.

Suggested Citation

  • Matthew Goulty & Gaelle Botton-Amiot & Ezio Rosato & Simon G. Sprecher & Roberto Feuda, 2023. "The monoaminergic system is a bilaterian innovation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39030-2
    DOI: 10.1038/s41467-023-39030-2
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    References listed on IDEAS

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    1. F. Lemoine & J.-B. Domelevo Entfellner & E. Wilkinson & D. Correia & M. Dávila Felipe & T. Oliveira & O. Gascuel, 2018. "Renewing Felsenstein’s phylogenetic bootstrap in the era of big data," Nature, Nature, vol. 556(7702), pages 452-456, April.
    2. Casey W. Dunn & Andreas Hejnol & David Q. Matus & Kevin Pang & William E. Browne & Stephen A. Smith & Elaine Seaver & Greg W. Rouse & Matthias Obst & Gregory D. Edgecombe & Martin V. Sørensen & Steven, 2008. "Broad phylogenomic sampling improves resolution of the animal tree of life," Nature, Nature, vol. 452(7188), pages 745-749, April.
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    1. Minjun Jin & Wanqing Li & Zhongyu Ji & Guotao Di & Meng Yuan & Yifan Zhang & Yunsi Kang & Chengtian Zhao, 2024. "Coordinated cellular behavior regulated by epinephrine neurotransmitters in the nerveless placozoa," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Christine Guzman & Kurato Mohri & Ryotaro Nakamura & Minato Miyake & Yuko Tsuchiya & Kentaro Tomii & Hiroshi Watanabe, 2024. "Neuronal and non-neuronal functions of the synaptic cell adhesion molecule neurexin in Nematostella vectensis," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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