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A population of Vasa2 and Piwi1 expressing cells generates germ cells and neurons in a sea anemone

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  • Paula Miramón-Puértolas

    (University of Bergen)

  • Eudald Pascual-Carreras

    (University of Bergen)

  • Patrick R. H. Steinmetz

    (University of Bergen)

Abstract

Germline segregation, essential for protecting germ cells against mutations, occurs during early embryogenesis in vertebrates, insects and nematodes. Highly regenerative animals (e.g., cnidarians), however, retain stem cells with both germinal and somatic potentials throughout adulthood, but their biology and evolution remain poorly understood. Among cnidarians (e.g., sea anemones, jellyfish), stem cells are only known in few hydrozoans (e.g., Hydra). Here, we identify and characterize a rare, multipotent population of stem and/or progenitor cells expressing the conserved germline and multipotency proteins Vasa2 and Piwi1 in the sea anemone Nematostella vectensis. Using piwi1 and vasa2 transgenic reporter lines, we reveal that the Vasa2+/Piwi1+ cell population generates not only gametes, but also a diversity of proliferative somatic cells, including neural progenitors, in juveniles and adults. Our work has uncovered a multipotent population of Vasa2+/Piwi1+ stem/progenitor cells that forms the cellular basis to understand body plasticity and regenerative capacities in sea anemones and corals.

Suggested Citation

  • Paula Miramón-Puértolas & Eudald Pascual-Carreras & Patrick R. H. Steinmetz, 2024. "A population of Vasa2 and Piwi1 expressing cells generates germ cells and neurons in a sea anemone," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52806-4
    DOI: 10.1038/s41467-024-52806-4
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    References listed on IDEAS

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    1. Laura Baldassarre & Hua Ying & Adam M. Reitzel & Sören Franzenburg & Sebastian Fraune, 2022. "Microbiota mediated plasticity promotes thermal adaptation in the sea anemone Nematostella vectensis," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Yulia Kraus & Andy Aman & Ulrich Technau & Grigory Genikhovich, 2016. "Pre-bilaterian origin of the blastoporal axial organizer," Nature Communications, Nature, vol. 7(1), pages 1-9, September.
    3. Ryan E. Hulett & Julian O. Kimura & D. Marcela Bolaños & Yi-Jyun Luo & Carlos Rivera-López & Lorenzo Ricci & Mansi Srivastava, 2023. "Acoel single-cell atlas reveals expression dynamics and heterogeneity of adult pluripotent stem cells," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Shunsuke Sogabe & William L. Hatleberg & Kevin M. Kocot & Tahsha E. Say & Daniel Stoupin & Kathrein E. Roper & Selene L. Fernandez-Valverde & Sandie M. Degnan & Bernard M. Degnan, 2019. "Pluripotency and the origin of animal multicellularity," Nature, Nature, vol. 570(7762), pages 519-522, June.
    5. Minjie Hu & Xiaobin Zheng & Chen-Ming Fan & Yixian Zheng, 2020. "Lineage dynamics of the endosymbiotic cell type in the soft coral Xenia," Nature, Nature, vol. 582(7813), pages 534-538, June.
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