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SoxC and MmpReg promote blastema formation in whole-body regeneration of fragmenting potworms Enchytraeus japonensis

Author

Listed:
  • Toshiyuki Fujita

    (Teikyo University)

  • Naoya Aoki

    (Teikyo University)

  • Chihiro Mori

    (Teikyo University)

  • Koichi J. Homma

    (Teikyo University)

  • Shinji Yamaguchi

    (Teikyo University)

Abstract

Regeneration in many animals involves the formation of a blastema, which differentiates and organizes into the appropriate missing body parts. Although the mechanisms underlying blastema formation are often fundamental to regeneration biology, information on the cellular and molecular basis of blastema formation remains limited. Here, we focus on a fragmenting potworm (Enchytraeus japonensis), which can regenerate its whole body from small fragments. We find soxC and mmpReg as upregulated genes in the blastema. RNAi of soxC and mmpReg reduce the number of blastema cells, indicating that soxC and mmpReg promote blastema formation. Expression analyses show that soxC-expressing cells appear to gradually accumulate in blastema and constitute a large part of the blastema. Additionally, similar expression dynamics of SoxC orthologue genes in frog (Xenopus laevis) are found in the regeneration blastema of tadpole tail. Our findings provide insights into the cellular and molecular mechanisms underlying blastema formation across species.

Suggested Citation

  • Toshiyuki Fujita & Naoya Aoki & Chihiro Mori & Koichi J. Homma & Shinji Yamaguchi, 2024. "SoxC and MmpReg promote blastema formation in whole-body regeneration of fragmenting potworms Enchytraeus japonensis," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50865-1
    DOI: 10.1038/s41467-024-50865-1
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    References listed on IDEAS

    as
    1. Qi Miao & Matthew C. Hill & Fengju Chen & Qianxing Mo & Amy T. Ku & Carlos Ramos & Elisabeth Sock & Véronique Lefebvre & Hoang Nguyen, 2019. "SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair," Nature Communications, Nature, vol. 10(1), pages 1-20, December.
    2. Ryan E. Hulett & Julian O. Kimura & D. Marcela Bolaños & Yi-Jyun Luo & Carlos Rivera-López & Lorenzo Ricci & Mansi Srivastava, 2023. "Acoel single-cell atlas reveals expression dynamics and heterogeneity of adult pluripotent stem cells," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
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