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From discoveries in ageing research to therapeutics for healthy ageing

Author

Listed:
  • Judith Campisi

    (Buck Institute for Research on Aging)

  • Pankaj Kapahi

    (Buck Institute for Research on Aging)

  • Gordon J. Lithgow

    (Buck Institute for Research on Aging)

  • Simon Melov

    (Buck Institute for Research on Aging)

  • John C. Newman

    (Buck Institute for Research on Aging)

  • Eric Verdin

    (Buck Institute for Research on Aging)

Abstract

For several decades, understanding ageing and the processes that limit lifespan have challenged biologists. Thirty years ago, the biology of ageing gained unprecedented scientific credibility through the identification of gene variants that extend the lifespan of multicellular model organisms. Here we summarize the milestones that mark this scientific triumph, discuss different ageing pathways and processes, and suggest that ageing research is entering a new era that has unique medical, commercial and societal implications. We argue that this era marks an inflection point, not only in ageing research but also for all biological research that affects the human healthspan.

Suggested Citation

  • Judith Campisi & Pankaj Kapahi & Gordon J. Lithgow & Simon Melov & John C. Newman & Eric Verdin, 2019. "From discoveries in ageing research to therapeutics for healthy ageing," Nature, Nature, vol. 571(7764), pages 183-192, July.
    • Handle: RePEc:nat:nature:v:571:y:2019:i:7764:d:10.1038_s41586-019-1365-2
    DOI: 10.1038/s41586-019-1365-2
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    Cited by:

    1. Qing Zou & Yingsi Lai & Zhao-Rong Lun, 2023. "Exploring the Association between Oxygen Concentration and Life Expectancy in China: A Quantitative Analysis," IJERPH, MDPI, vol. 20(2), pages 1-13, January.
    2. Scott, Andrew J., 2023. "The economics of longevity – An introduction," The Journal of the Economics of Ageing, Elsevier, vol. 24(C).
    3. Rupesh S. Patel & Rodrigo Romero & Emma V. Watson & Anthony C. Liang & Megan Burger & Peter M. K. Westcott & Kim L. Mercer & Roderick T. Bronson & Eric C. Wooten & Arjun Bhutkar & Tyler Jacks & Stephe, 2022. "A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    4. Damien S. E. Broekharst & Sjaak Bloem & Marije Blok & Mariët Raatgever & Nathascha Hanzen & Jasmien J. E. de Vette, 2023. "Determining the Appropriate Support for Older Adults with Different Levels of Vitality and Health-Related Quality of Life: An Explanatory Study," IJERPH, MDPI, vol. 20(11), pages 1-11, June.
    5. Takayoshi Sasako & Toshihiro Umehara & Kotaro Soeda & Kazuma Kaneko & Miho Suzuki & Naoki Kobayashi & Yukiko Okazaki & Miwa Tamura-Nakano & Tomoki Chiba & Domenico Accili & C. Ronald Kahn & Tetsuo Nod, 2022. "Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    6. Old, Jonathan & Scott, Andrew, 2023. "Healthy ageing trends in England between 2002 to 2018: Improving but slowing and unequal," Department of Economics, Working Paper Series qt759110mx, Department of Economics, Institute for Business and Economic Research, UC Berkeley.
    7. Cox, Lynne S., 2022. "Therapeutic approaches to treat and prevent age-related diseases through understanding the underlying biological drivers of ageing," The Journal of the Economics of Ageing, Elsevier, vol. 23(C).
    8. Xueqing Wang & Quanlong Jiang & Hongdao Zhang & Zhidong He & Yuanyuan Song & Yifan Chen & Na Tang & Yifei Zhou & Yiping Li & Adam Antebi & Ligang Wu & Jing-Dong J. Han & Yidong Shen, 2024. "Tissue-specific profiling of age-dependent miRNAomic changes in Caenorhabditis elegans," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    9. Betz, Ulrich A.K. & Arora, Loukik & Assal, Reem A. & Azevedo, Hatylas & Baldwin, Jeremy & Becker, Michael S. & Bostock, Stefan & Cheng, Vinton & Egle, Tobias & Ferrari, Nicola & Schneider-Futschik, El, 2023. "Game changers in science and technology - now and beyond," Technological Forecasting and Social Change, Elsevier, vol. 193(C).
    10. Seoyeon Lee & Mohammad Naimul Islam & Kaveh Boostanpour & Dvir Aran & Guangchun Jin & Stephanie Christenson & Michael A. Matthay & Walter L. Eckalbar & Daryle J. DePianto & Joseph R. Arron & Liam Mage, 2021. "Molecular programs of fibrotic change in aging human lung," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    11. Zi Wang & Lina Zou & Yiyan Zhang & Mengnan Zhu & Shuxian Zhang & Di Wu & Jianfeng Lan & Xiao Zang & Qi Wang & Hanxin Zhang & Zixing Wu & Huanhu Zhu & Di Chen, 2023. "ACS-20/FATP4 mediates the anti-ageing effect of dietary restriction in C. elegans," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    12. Hina Kosakamoto & Fumiaki Obata & Junpei Kuraishi & Hide Aikawa & Rina Okada & Joshua N. Johnstone & Taro Onuma & Matthew D. W. Piper & Masayuki Miura, 2023. "Early-adult methionine restriction reduces methionine sulfoxide and extends lifespan in Drosophila," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    13. Jorge Navarro & Miguel Cañete & Francisco J. Olivera & Marta Gil-Lacruz & Ana Gil-Lacruz & Pedro C. Marijuán, 2022. "The Cost of Loneliness: Assessing the Social Relationships of the Elderly via an Abbreviated Sociotype Questionnaire for inside and outside the Clinic," IJERPH, MDPI, vol. 19(3), pages 1-15, January.
    14. Naina Bhatia-Dey & Thomas Heinbockel, 2021. "The Olfactory System as Marker of Neurodegeneration in Aging, Neurological and Neuropsychiatric Disorders," IJERPH, MDPI, vol. 18(13), pages 1-15, June.
    15. Old, Jonathan & Scott, Andrew, 2023. "Healthy ageing trends in England between 2002 to 2018: Improving but slowing and unequal," The Journal of the Economics of Ageing, Elsevier, vol. 26(C).
    16. Jinjie Duan & Wenhui Dong & Guangyan Wang & Wenjing Xiu & Guangyin Pu & Jingwen Xu & Chenji Ye & Xu Zhang & Yi Zhu & Chunjiong Wang, 2023. "Senescence-associated 13-HODE production promotes age-related liver steatosis by directly inhibiting catalase activity," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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