IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-12821-2.html
   My bibliography  Save this article

A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing

Author

Listed:
  • Yifei Zhou

    (University of Chinese Academy of Sciences, Chinese Academy of Sciences)

  • Xueqing Wang

    (University of Chinese Academy of Sciences, Chinese Academy of Sciences)

  • Mengjiao Song

    (University of Chinese Academy of Sciences, Chinese Academy of Sciences)

  • Zhidong He

    (University of Chinese Academy of Sciences, Chinese Academy of Sciences)

  • Guizhong Cui

    (University of Chinese Academy of Sciences, Chinese Academy of Sciences)

  • Guangdun Peng

    (Chinese Academy of Sciences
    Guangzhou Regenerative Medicine and Health Guangdong Laboratory (GRMH-GDL))

  • Christoph Dieterich

    (Klaus Tschira Institute for Integrative Computational Cardiology and Department of Internal Medicine III, University Hospital Heidelberg)

  • Adam Antebi

    (Max Planck Institute for Biology of Ageing
    University of Cologne)

  • Naihe Jing

    (University of Chinese Academy of Sciences, Chinese Academy of Sciences)

  • Yidong Shen

    (University of Chinese Academy of Sciences, Chinese Academy of Sciences)

Abstract

Macroautophagy, a key player in protein quality control, is proposed to be systematically impaired in distinct tissues and causes coordinated disruption of protein homeostasis and ageing throughout the body. Although tissue-specific changes in autophagy and ageing have been extensively explored, the mechanism underlying the inter-tissue regulation of autophagy with ageing is poorly understood. Here, we show that a secreted microRNA, mir-83/miR-29, controls the age-related decrease in macroautophagy across tissues in Caenorhabditis elegans. Upregulated in the intestine by hsf-1/HSF1 with age, mir-83 is transported across tissues potentially via extracellular vesicles and disrupts macroautophagy by suppressing CUP-5/MCOLN, a vital autophagy regulator, autonomously in the intestine as well as non-autonomously in body wall muscle. Mutating mir-83 thereby enhances macroautophagy in different tissues, promoting protein homeostasis and longevity. These findings thus identify a microRNA-based mechanism to coordinate the decreasing macroautophagy in various tissues with age.

Suggested Citation

  • Yifei Zhou & Xueqing Wang & Mengjiao Song & Zhidong He & Guizhong Cui & Guangdun Peng & Christoph Dieterich & Adam Antebi & Naihe Jing & Yidong Shen, 2019. "A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12821-2
    DOI: 10.1038/s41467-019-12821-2
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-12821-2
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-12821-2?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Xueqing Wang & Quanlong Jiang & Hongdao Zhang & Zhidong He & Yuanyuan Song & Yifan Chen & Na Tang & Yifei Zhou & Yiping Li & Adam Antebi & Ligang Wu & Jing-Dong J. Han & Yidong Shen, 2024. "Tissue-specific profiling of age-dependent miRNAomic changes in Caenorhabditis elegans," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Weina Xu & Jinyi Liu & Huan Qi & Ruolin Si & Zhiguang Zhao & Zhiju Tao & Yuchuan Bai & Shipeng Hu & Xiaohan Sun & Yulin Cong & Haoye Zhang & Duchangjiang Fan & Long Xiao & Yangyang Wang & Yongbin Li &, 2024. "A lineage-resolved cartography of microRNA promoter activity in C. elegans empowers multidimensional developmental analysis," Nature Communications, Nature, vol. 15(1), pages 1-23, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12821-2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.