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Quantum plasmonics pushes chiral sensing limit to single molecules: a paradigm for chiral biodetections

Author

Listed:
  • Chi Zhang

    (Wuhan University)

  • Huatian Hu

    (Wuhan Institute of Technology
    Istituto Italiano di Tecnologia)

  • Chunmiao Ma

    (Huazhong University of Science and Technology)

  • Yawen Li

    (Wuhan University)

  • Xujie Wang

    (Wuhan University)

  • Dongyao Li

    (Huazhong University of Science and Technology)

  • Artur Movsesyan

    (University of Electronic Science and Technology of China
    Ohio University)

  • Zhiming Wang

    (University of Electronic Science and Technology of China)

  • Alexander Govorov

    (Ohio University)

  • Quan Gan

    (Huazhong University of Science and Technology)

  • Tao Ding

    (Wuhan University)

Abstract

Chiral sensing of single molecules is vital for the understanding of chirality and their applications in biomedicine. However, current technologies face severe limitations in achieving single-molecule sensitivity. Here we overcome these limitations by designing a tunable chiral supramolecular plasmonic system made of helical oligoamide sequences (OS) and nanoparticle-on-mirror (NPoM) resonator, which works across the classical and quantum regimes. Our design enhances the chiral sensitivity in the quantum tunnelling regime despite of the reduced local E-field, which is due to the strong Coulomb interactions between the chiral OSs and the achiral NPoMs and the additional enhancement from tunnelling electrons. A minimum of four molecules per single-Au particle can be detected, which allows for the detection of an enantiomeric excess within a monolayer, manifesting great potential for the chiral sensing of single molecules.

Suggested Citation

  • Chi Zhang & Huatian Hu & Chunmiao Ma & Yawen Li & Xujie Wang & Dongyao Li & Artur Movsesyan & Zhiming Wang & Alexander Govorov & Quan Gan & Tao Ding, 2024. "Quantum plasmonics pushes chiral sensing limit to single molecules: a paradigm for chiral biodetections," Nature Communications, Nature, vol. 15(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-42719-z
    DOI: 10.1038/s41467-023-42719-z
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    References listed on IDEAS

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