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Straightforward synthesis of functionalized γ-Lactams using impure CO2 stream as the carbon source

Author

Listed:
  • Yuman Qin

    (University of Bayreuth
    Universiteit Antwerpen)

  • Robin Cauwenbergh

    (Universiteit Antwerpen)

  • Suman Pradhan

    (University of Bayreuth
    Universiteit Antwerpen)

  • Rakesh Maiti

    (University of Bayreuth
    Universiteit Antwerpen)

  • Philippe Franck

    (Universiteit Antwerpen)

  • Shoubhik Das

    (University of Bayreuth
    Universiteit Antwerpen)

Abstract

Direct utilization of CO2 into organic synthesis finds enormous applications to synthesize pharmaceuticals and fine chemicals. However, pure CO2 gas is essential to achieve these transformations, and the purification of CO2 is highly cost and energy intensive. Considering this, we describe a straightforward synthetic route for the synthesis of γ-lactams, a pivotal core structure of bioactive molecules, by using commercially available starting materials (alkenes and amines) and impure CO2 stream (exhaust gas is collected from the car) as the carbon source. This blueprint features a broad scope, excellent functional group compatibility and application to the late-stage transformation of existing pharmaceuticals and natural products to synthesize functionalized γ-lactams. We believe that our strategy will provide direct access to γ-lactams in a very sustainable way and will also enhance the Carbon Capture and Utilization (CCU) strategy.

Suggested Citation

  • Yuman Qin & Robin Cauwenbergh & Suman Pradhan & Rakesh Maiti & Philippe Franck & Shoubhik Das, 2023. "Straightforward synthesis of functionalized γ-Lactams using impure CO2 stream as the carbon source," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43289-w
    DOI: 10.1038/s41467-023-43289-w
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    References listed on IDEAS

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    1. Frederick R. Maxfield & Ira Tabas, 2005. "Role of cholesterol and lipid organization in disease," Nature, Nature, vol. 438(7068), pages 612-621, December.
    2. Qiang Liu & Lipeng Wu & Ralf Jackstell & Matthias Beller, 2015. "Using carbon dioxide as a building block in organic synthesis," Nature Communications, Nature, vol. 6(1), pages 1-15, May.
    3. Guang-Mei Cao & Xin-Long Hu & Li-Li Liao & Si-Shun Yan & Lei Song & Jason J. Chruma & Li Gong & Da-Gang Yu, 2021. "Visible-light photoredox-catalyzed umpolung carboxylation of carbonyl compounds with CO2," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    4. Rui Sang & Yuya Hu & Rauf Razzaq & Guillaume Mollaert & Hanan Atia & Ursula Bentrup & Muhammad Sharif & Helfried Neumann & Henrik Junge & Ralf Jackstell & Bert U. W. Maes & Matthias Beller, 2022. "A practical concept for catalytic carbonylations using carbon dioxide," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
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