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Role of cholesterol and lipid organization in disease

Author

Listed:
  • Frederick R. Maxfield

    (Weill Medical College of Cornell University)

  • Ira Tabas

    (Cell Biology, and Physiology & Cellular Biophysics, Columbia University College of Physicians and Surgeons)

Abstract

Membrane lipids are essential for biological functions ranging from membrane trafficking to signal transduction. The composition of lipid membranes influences their organization and properties, so it is not surprising that disorders in lipid metabolism and transport have a role in human disease. Significant recent progress has enhanced our understanding of the molecular and cellular basis of lipid-associated disorders such as Tangier disease, Niemann–Pick disease type C and atherosclerosis. These insights have also led to improved understanding of normal physiology.

Suggested Citation

  • Frederick R. Maxfield & Ira Tabas, 2005. "Role of cholesterol and lipid organization in disease," Nature, Nature, vol. 438(7068), pages 612-621, December.
    • Handle: RePEc:nat:nature:v:438:y:2005:i:7068:d:10.1038_nature04399
    DOI: 10.1038/nature04399
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    Cited by:

    1. Yuman Qin & Robin Cauwenbergh & Suman Pradhan & Rakesh Maiti & Philippe Franck & Shoubhik Das, 2023. "Straightforward synthesis of functionalized γ-Lactams using impure CO2 stream as the carbon source," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    2. Maria Casas & Karl D. Murray & Keiko Hino & Nicholas C. Vierra & Sergi Simó & James S. Trimmer & Rose E. Dixon & Eamonn J. Dickson, 2023. "NPC1-dependent alterations in KV2.1–CaV1.2 nanodomains drive neuronal death in models of Niemann-Pick Type C disease," Nature Communications, Nature, vol. 14(1), pages 1-22, December.

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