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Deep optoacoustic localization microangiography of ischemic stroke in mice

Author

Listed:
  • Xosé Luís Deán-Ben

    (University of Zurich
    ETH Zurich)

  • Justine Robin

    (University of Zurich
    ETH Zurich)

  • Daniil Nozdriukhin

    (University of Zurich
    ETH Zurich)

  • Ruiqing Ni

    (University of Zurich
    ETH Zurich
    Zurich Neuroscience Center)

  • Jim Zhao

    (University of Zurich
    ETH Zurich)

  • Chaim Glück

    (Institute of Pharmacology and Toxicology, University of Zurich, and Zurich Neuroscience Center)

  • Jeanne Droux

    (Zurich Neuroscience Center
    University Hospital and University of Zurich and University of Zurich)

  • Juan Sendón-Lago

    (University of Santiago de Compostela)

  • Zhenyue Chen

    (University of Zurich
    ETH Zurich)

  • Quanyu Zhou

    (University of Zurich
    ETH Zurich)

  • Bruno Weber

    (Institute of Pharmacology and Toxicology, University of Zurich, and Zurich Neuroscience Center)

  • Susanne Wegener

    (Zurich Neuroscience Center
    University Hospital and University of Zurich and University of Zurich)

  • Anxo Vidal

    (University of Santiago de Compostela)

  • Michael Arand

    (University of Zurich)

  • Mohamad El Amki

    (Zurich Neuroscience Center
    University Hospital and University of Zurich and University of Zurich)

  • Daniel Razansky

    (University of Zurich
    ETH Zurich
    Zurich Neuroscience Center)

Abstract

Super-resolution optoacoustic imaging of microvascular structures deep in mammalian tissues has so far been impeded by strong absorption from densely-packed red blood cells. Here we devised 5 µm biocompatible dichloromethane-based microdroplets exhibiting several orders of magnitude higher optical absorption than red blood cells at near-infrared wavelengths, thus enabling single-particle detection in vivo. We demonstrate non-invasive three-dimensional microangiography of the mouse brain beyond the acoustic diffraction limit (

Suggested Citation

  • Xosé Luís Deán-Ben & Justine Robin & Daniil Nozdriukhin & Ruiqing Ni & Jim Zhao & Chaim Glück & Jeanne Droux & Juan Sendón-Lago & Zhenyue Chen & Quanyu Zhou & Bruno Weber & Susanne Wegener & Anxo Vida, 2023. "Deep optoacoustic localization microangiography of ischemic stroke in mice," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39069-1
    DOI: 10.1038/s41467-023-39069-1
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    References listed on IDEAS

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    1. Leila Ghanbari & Russell E. Carter & Mathew L. Rynes & Judith Dominguez & Gang Chen & Anant Naik & Jia Hu & Md Abdul Kader Sagar & Lenora Haltom & Nahom Mossazghi & Madelyn M. Gray & Sarah L. West & K, 2019. "Cortex-wide neural interfacing via transparent polymer skulls," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    2. Claudia Errico & Juliette Pierre & Sophie Pezet & Yann Desailly & Zsolt Lenkei & Olivier Couture & Mickael Tanter, 2015. "Ultrafast ultrasound localization microscopy for deep super-resolution vascular imaging," Nature, Nature, vol. 527(7579), pages 499-502, November.
    3. Stratis Tzoumas & Antonio Nunes & Ivan Olefir & Stefan Stangl & Panagiotis Symvoulidis & Sarah Glasl & Christine Bayer & Gabriele Multhoff & Vasilis Ntziachristos, 2016. "Eigenspectra optoacoustic tomography achieves quantitative blood oxygenation imaging deep in tissues," Nature Communications, Nature, vol. 7(1), pages 1-10, November.
    4. Ed S. Lein & Michael J. Hawrylycz & Nancy Ao & Mikael Ayres & Amy Bensinger & Amy Bernard & Andrew F. Boe & Mark S. Boguski & Kevin S. Brockway & Emi J. Byrnes & Lin Chen & Li Chen & Tsuey-Ming Chen &, 2007. "Genome-wide atlas of gene expression in the adult mouse brain," Nature, Nature, vol. 445(7124), pages 168-176, January.
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