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Mitochondria from osteolineage cells regulate myeloid cell-mediated bone resorption

Author

Listed:
  • Peng Ding

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Chuan Gao

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Jian Zhou

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Jialun Mei

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Gan Li

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Delin Liu

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Hao Li

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Peng Liao

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Meng Yao

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Bingqi Wang

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Yafei Lu

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Xiaoyuan Peng

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Chenyi Jiang

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Jimin Yin

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Yigang Huang

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Minghao Zheng

    (University of Western Australia)

  • Youshui Gao

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Changqing Zhang

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Junjie Gao

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

Abstract

Interactions between osteolineage cells and myeloid cells play important roles in maintaining skeletal homeostasis. Herein, we find that osteolineage cells transfer mitochondria to myeloid cells. Impairment of the transfer of mitochondria by deleting MIRO1 in osteolineage cells leads to increased myeloid cell commitment toward osteoclastic lineage cells and promotes bone resorption. In detail, impaired mitochondrial transfer from osteolineage cells alters glutathione metabolism and protects osteoclastic lineage cells from ferroptosis, thus promoting osteoclast activities. Furthermore, mitochondrial transfer from osteolineage cells to myeloid cells is involved in the regulation of glucocorticoid-induced osteoporosis, and glutathione depletion alleviates the progression of glucocorticoid-induced osteoporosis. These findings reveal an unappreciated mechanism underlying the interaction between osteolineage cells and myeloid cells to regulate skeletal metabolic homeostasis and provide insights into glucocorticoid-induced osteoporosis progression.

Suggested Citation

  • Peng Ding & Chuan Gao & Jian Zhou & Jialun Mei & Gan Li & Delin Liu & Hao Li & Peng Liao & Meng Yao & Bingqi Wang & Yafei Lu & Xiaoyuan Peng & Chenyi Jiang & Jimin Yin & Yigang Huang & Minghao Zheng &, 2024. "Mitochondria from osteolineage cells regulate myeloid cell-mediated bone resorption," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49159-3
    DOI: 10.1038/s41467-024-49159-3
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    1. Simón Méndez-Ferrer & Tatyana V. Michurina & Francesca Ferraro & Amin R. Mazloom & Ben D. MacArthur & Sergio A. Lira & David T. Scadden & Avi Ma’ayan & Grigori N. Enikolopov & Paul S. Frenette, 2010. "Mesenchymal and haematopoietic stem cells form a unique bone marrow niche," Nature, Nature, vol. 466(7308), pages 829-834, August.
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