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Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance

Author

Listed:
  • Zixiao Yin

    (Capital Medical University)

  • Ruoyu Ma

    (Capital Medical University)

  • Qi An

    (Capital Medical University)

  • Yichen Xu

    (Capital Medical University)

  • Yifei Gan

    (Capital Medical University)

  • Guanyu Zhu

    (Capital Medical University)

  • Yin Jiang

    (Capital Medical University)

  • Ning Zhang

    (Capital Medical University)

  • Anchao Yang

    (Capital Medical University)

  • Fangang Meng

    (Capital Medical University)

  • Andrea A. Kühn

    (Charité – Universitätsmedizin Berlin
    Charité – Universitätsmedizin Berlin)

  • Hagai Bergman

    (The Hebrew University
    The Hebrew University
    Hadassah Medical Center)

  • Wolf-Julian Neumann

    (Charité – Universitätsmedizin Berlin)

  • Jianguo Zhang

    (Capital Medical University
    Capital Medical University
    Beijing Key Laboratory of Neurostimulation)

Abstract

Parkinson’s disease (PD) is associated with excessive beta activity in the basal ganglia. Brain sensing implants aim to leverage this biomarker for demand-dependent adaptive stimulation. Sleep disturbance is among the most common non-motor symptoms in PD, but its relationship with beta activity is unknown. To investigate the clinical potential of beta activity as a biomarker for sleep quality in PD, we recorded pallidal local field potentials during polysomnography in PD patients off dopaminergic medication and compared the results to dystonia patients. PD patients exhibited sustained and elevated beta activity across wakefulness, rapid eye movement (REM), and non-REM sleep, which was correlated with sleep disturbance. Simulation of adaptive stimulation revealed that sleep-related beta activity changes remain unaccounted for by current algorithms, with potential negative outcomes in sleep quality and overall quality of life for patients.

Suggested Citation

  • Zixiao Yin & Ruoyu Ma & Qi An & Yichen Xu & Yifei Gan & Guanyu Zhu & Yin Jiang & Ning Zhang & Anchao Yang & Fangang Meng & Andrea A. Kühn & Hagai Bergman & Wolf-Julian Neumann & Jianguo Zhang, 2023. "Pathological pallidal beta activity in Parkinson’s disease is sustained during sleep and associated with sleep disturbance," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41128-6
    DOI: 10.1038/s41467-023-41128-6
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    References listed on IDEAS

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    1. Charles R. Harris & K. Jarrod Millman & Stéfan J. Walt & Ralf Gommers & Pauli Virtanen & David Cournapeau & Eric Wieser & Julian Taylor & Sebastian Berg & Nathaniel J. Smith & Robert Kern & Matti Picu, 2020. "Array programming with NumPy," Nature, Nature, vol. 585(7825), pages 357-362, September.
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    Cited by:

    1. Jackson N. Cagle & Tiberio de Araujo & Kara A. Johnson & John Yu & Lauren Fanty & Filipe P. Sarmento & Simon Little & Michael S. Okun & Joshua K. Wong & Coralie de Hemptinne, 2024. "Chronic intracranial recordings in the globus pallidus reveal circadian rhythms in Parkinson’s disease," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    2. Md Fahim Anjum & Clay Smyth & Rafael Zuzuárregui & Derk Jan Dijk & Philip A. Starr & Timothy Denison & Simon Little, 2024. "Multi-night cortico-basal recordings reveal mechanisms of NREM slow-wave suppression and spontaneous awakenings in Parkinson’s disease," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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