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Theranostic imaging and multimodal photodynamic therapy and immunotherapy using the mTOR signaling pathway

Author

Listed:
  • Huiling Zhou

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences Beijing)

  • Dongsheng Tang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences Beijing)

  • Yingjie Yu

    (Beijing University of Chemical Technology)

  • Lingpu Zhang

    (Beijing University of Chemical Technology)

  • Bin Wang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences Beijing)

  • Johannes Karges

    (Ruhr-University Bochum)

  • Haihua Xiao

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences Beijing)

Abstract

Tumor metastases are considered the leading cause of cancer-associated deaths. While clinically applied drugs have demonstrated to efficiently remove the primary tumor, metastases remain poorly accessible. To overcome this limitation, herein, the development of a theranostic nanomaterial by incorporating a chromophore for imaging and a photosensitizer for treatment of metastatic tumor sites is presented. The mechanism of action reveals that the nanoparticles are able to intervene by local generation of cellular damage through photodynamic therapy as well as by systemic induction of an immune response by immunotherapy upon inhibition of the mTOR signaling pathway which is of crucial importance for tumor onset, progression and metastatic spreading. The nanomaterial is able to strongly reduce the volume of the primary tumor as well as eradicates tumor metastases in a metastatic breast cancer and a multi-drug resistant patient-derived hepatocellular carcinoma models in female mice.

Suggested Citation

  • Huiling Zhou & Dongsheng Tang & Yingjie Yu & Lingpu Zhang & Bin Wang & Johannes Karges & Haihua Xiao, 2023. "Theranostic imaging and multimodal photodynamic therapy and immunotherapy using the mTOR signaling pathway," Nature Communications, Nature, vol. 14(1), pages 1-23, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40826-5
    DOI: 10.1038/s41467-023-40826-5
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    References listed on IDEAS

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    1. K. Hayashi & F. Nikolos & Y. C. Lee & A. Jain & E. Tsouko & H. Gao & A. Kasabyan & H. E. Leung & A. Osipov & S. Y. Jung & A. V. Kurtova & K. S. Chan, 2020. "Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    2. Joan Massagué & Anna C. Obenauf, 2016. "Metastatic colonization by circulating tumour cells," Nature, Nature, vol. 529(7586), pages 298-306, January.
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    Cited by:

    1. Dongsheng Tang & Minhui Cui & Bin Wang & Ganghao Liang & Hanchen Zhang & Haihua Xiao, 2024. "Nanoparticles destabilizing the cell membranes triggered by NIR light for cancer imaging and photo-immunotherapy," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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