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Metastatic colonization by circulating tumour cells

Author

Listed:
  • Joan Massagué

    (Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center)

  • Anna C. Obenauf

    (Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center
    Present address: Research Institute of Molecular Pathology, Vienna Biocenter, 1030 Vienna, Austria.)

Abstract

Metastasis is the main cause of death in people with cancer. To colonize distant organs, circulating tumour cells must overcome many obstacles through mechanisms that we are only now starting to understand. These include infiltrating distant tissue, evading immune defences, adapting to supportive niches, surviving as latent tumour-initiating seeds and eventually breaking out to replace the host tissue. They make metastasis a highly inefficient process. However, once metastases have been established, current treatments frequently fail to provide durable responses. An improved understanding of the mechanistic determinants of such colonization is needed to better prevent and treat metastatic cancer.

Suggested Citation

  • Joan Massagué & Anna C. Obenauf, 2016. "Metastatic colonization by circulating tumour cells," Nature, Nature, vol. 529(7586), pages 298-306, January.
    • Handle: RePEc:nat:nature:v:529:y:2016:i:7586:d:10.1038_nature17038
    DOI: 10.1038/nature17038
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    Cited by:

    1. Rong Xiao & Deshu Xu & Meili Zhang & Zhanghua Chen & Li Cheng & Songjie Du & Mingfei Lu & Tonghai Zhou & Ruoyan Li & Fan Bai & Yue Huang, 2024. "Aneuploid embryonic stem cells drive teratoma metastasis," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Huiling Zhou & Dongsheng Tang & Yingjie Yu & Lingpu Zhang & Bin Wang & Johannes Karges & Haihua Xiao, 2023. "Theranostic imaging and multimodal photodynamic therapy and immunotherapy using the mTOR signaling pathway," Nature Communications, Nature, vol. 14(1), pages 1-23, December.
    3. Huapan Fang & Zhaopei Guo & Jie Chen & Lin Lin & Yingying Hu & Yanhui Li & Huayu Tian & Xuesi Chen, 2021. "Combination of epigenetic regulation with gene therapy-mediated immune checkpoint blockade induces anti-tumour effects and immune response in vivo," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
    4. Zhiyuan Zheng & Ya-nan Li & Shanfen Jia & Mengting Zhu & Lijuan Cao & Min Tao & Jingting Jiang & Shenghua Zhan & Yongjing Chen & Ping-Jin Gao & Weiguo Hu & Ying Wang & Changshun Shao & Yufang Shi, 2021. "Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    5. Kaiyuan Wang & Xuanbo Zhang & Hao Ye & Xia Wang & Zhijin Fan & Qi Lu & Songhao Li & Jian Zhao & Shunzhe Zheng & Zhonggui He & Qianqian Ni & Xiaoyuan Chen & Jin Sun, 2023. "Biomimetic nanovaccine-mediated multivalent IL-15 self-transpresentation (MIST) for potent and safe cancer immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    6. W. Dean Pontius & Ellen S. Hong & Zachary J. Faber & Jeremy Gray & Craig D. Peacock & Ian Bayles & Katreya Lovrenert & Diana H. Chin & Berkley E. Gryder & Cynthia F. Bartels & Peter C. Scacheri, 2023. "Temporal chromatin accessibility changes define transcriptional states essential for osteosarcoma metastasis," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    7. Meirion Raymant & Yuliana Astuti & Laura Alvaro-Espinosa & Daniel Green & Valeria Quaranta & Gaia Bellomo & Mark Glenn & Vatshala Chandran-Gorner & Daniel H. Palmer & Christopher Halloran & Paula Ghan, 2024. "Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

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