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Effects of COVID-19 vaccination and previous infection on Omicron SARS-CoV-2 infection and relation with serology

Author

Listed:
  • Brechje Gier

    (National Institute for Public Health and the Environment)

  • Anne J. Huiberts

    (National Institute for Public Health and the Environment)

  • Christina E. Hoeve

    (National Institute for Public Health and the Environment)

  • Gerco Hartog

    (National Institute for Public Health and the Environment
    Radboud Institute for Molecular Life Sciences, Radboudumc
    Radboud Center for Infectious Diseases, Radboudumc)

  • Henri Werkhoven

    (National Institute for Public Health and the Environment
    University Medical Center Utrecht, Utrecht University)

  • Rob Binnendijk

    (National Institute for Public Health and the Environment)

  • Susan J. M. Hahné

    (National Institute for Public Health and the Environment)

  • Hester E. Melker

    (National Institute for Public Health and the Environment)

  • Susan Hof

    (National Institute for Public Health and the Environment)

  • Mirjam J. Knol

    (National Institute for Public Health and the Environment)

Abstract

An increasing proportion of the population has acquired immunity through COVID-19 vaccination and previous SARS-CoV-2 infection, i.e., hybrid immunity, possibly affecting the risk of new infection. We aim to estimate the protective effect of previous infections and vaccinations on SARS-CoV-2 Omicron infection, using data from 43,257 adult participants in a prospective community-based cohort study in the Netherlands, collected between 10 January 2022 and 1 September 2022. Our results show that, for participants with 2, 3 or 4 prior immunizing events (vaccination or previous infection), hybrid immunity is more protective against infection with SARS-CoV-2 Omicron than vaccine-induced immunity, up to at least 30 weeks after the last immunizing event. Differences in risk of infection are partly explained by differences in anti-Spike RBD (S) antibody concentration, which is associated with risk of infection in a dose-response manner. Among participants with hybrid immunity, with one previous pre-Omicron infection, we do not observe a relevant difference in risk of Omicron infection by sequence of vaccination(s) and infection. Additional immunizing events increase the protection against infection, but not above the level of the first weeks after the previous event.

Suggested Citation

  • Brechje Gier & Anne J. Huiberts & Christina E. Hoeve & Gerco Hartog & Henri Werkhoven & Rob Binnendijk & Susan J. M. Hahné & Hester E. Melker & Susan Hof & Mirjam J. Knol, 2023. "Effects of COVID-19 vaccination and previous infection on Omicron SARS-CoV-2 infection and relation with serology," Nature Communications, Nature, vol. 14(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40195-z
    DOI: 10.1038/s41467-023-40195-z
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    References listed on IDEAS

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    1. Teresa Aydillo & Alexander Rombauts & Daniel Stadlbauer & Sadaf Aslam & Gabriela Abelenda-Alonso & Alba Escalera & Fatima Amanat & Kaijun Jiang & Florian Krammer & Jordi Carratala & Adolfo García-Sast, 2021. "Immunological imprinting of the antibody response in COVID-19 patients," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. Stijn P. Andeweg & Brechje Gier & Dirk Eggink & Caroline Ende & Noortje Maarseveen & Lubna Ali & Boris Vlaemynck & Raf Schepers & Susan J. M. Hahné & Chantal B. E. M. Reusken & Hester E. Melker & Susa, 2022. "Protection of COVID-19 vaccination and previous infection against Omicron BA.1, BA.2 and Delta SARS-CoV-2 infections," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
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