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SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals

Author

Listed:
  • Kaori Sano

    (Icahn School of Medicine at Mount Sinai)

  • Disha Bhavsar

    (Icahn School of Medicine at Mount Sinai)

  • Gagandeep Singh

    (Icahn School of Medicine at Mount Sinai)

  • Daniel Floda

    (Icahn School of Medicine at Mount Sinai)

  • Komal Srivastava

    (Icahn School of Medicine at Mount Sinai)

  • Charles Gleason

    (Icahn School of Medicine at Mount Sinai)

  • Juan Manuel Carreño

    (Icahn School of Medicine at Mount Sinai)

  • Viviana Simon

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Florian Krammer

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

Abstract

Immune responses at the respiratory mucosal interface are critical to prevent respiratory infections but it is unclear to what extent antigen specific mucosal secretory IgA (SIgA) antibodies are induced by mRNA vaccination in humans. Here we analyze paired serum and saliva samples from patients with and without prior coronavirus disease 2019 (COVID-19) at multiple time points pre and post severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination. Our results suggest mucosal SIgA responses induced by mRNA vaccination are impacted by pre-existing immunity. Indeed, vaccination induced a minimal mucosal SIgA response in individuals without pre-exposure to SARS-CoV-2 while SIgA induction after vaccination was more efficient in patients with a history of COVID-19.

Suggested Citation

  • Kaori Sano & Disha Bhavsar & Gagandeep Singh & Daniel Floda & Komal Srivastava & Charles Gleason & Juan Manuel Carreño & Viviana Simon & Florian Krammer, 2022. "SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32389-8
    DOI: 10.1038/s41467-022-32389-8
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    References listed on IDEAS

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    1. Weina Sun & Yonghong Liu & Fatima Amanat & Irene González-Domínguez & Stephen McCroskery & Stefan Slamanig & Lynda Coughlan & Victoria Rosado & Nicholas Lemus & Sonia Jangra & Raveen Rathnasinghe & Mi, 2021. "A Newcastle disease virus expressing a stabilized spike protein of SARS-CoV-2 induces protective immune responses," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Teresa Aydillo & Alexander Rombauts & Daniel Stadlbauer & Sadaf Aslam & Gabriela Abelenda-Alonso & Alba Escalera & Fatima Amanat & Kaijun Jiang & Florian Krammer & Jordi Carratala & Adolfo García-Sast, 2021. "Immunological imprinting of the antibody response in COVID-19 patients," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
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    1. Elena Mitsi & Mariana O. Diniz & Jesús Reiné & Andrea M. Collins & Ryan E. Robinson & Angela Hyder-Wright & Madlen Farrar & Konstantinos Liatsikos & Josh Hamilton & Onyia Onyema & Britta C. Urban & Ca, 2023. "Respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Aneesh Vijayan & Ronald Vogels & Rachel Groppo & Yi Jin & Selina Khan & Mirjam Kampen & Sytze Jorritsma & Satish Boedhoe & Miranda Baert & Harry Diepen & Harmjan Kuipers & Jan Serroyen & Jorge Reyes- , 2024. "A self-amplifying RNA RSV prefusion-F vaccine elicits potent immunity in pre-exposed and naïve non-human primates," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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