IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-32389-8.html
   My bibliography  Save this article

SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals

Author

Listed:
  • Kaori Sano

    (Icahn School of Medicine at Mount Sinai)

  • Disha Bhavsar

    (Icahn School of Medicine at Mount Sinai)

  • Gagandeep Singh

    (Icahn School of Medicine at Mount Sinai)

  • Daniel Floda

    (Icahn School of Medicine at Mount Sinai)

  • Komal Srivastava

    (Icahn School of Medicine at Mount Sinai)

  • Charles Gleason

    (Icahn School of Medicine at Mount Sinai)

  • Juan Manuel Carreño

    (Icahn School of Medicine at Mount Sinai)

  • Viviana Simon

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Florian Krammer

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

Abstract

Immune responses at the respiratory mucosal interface are critical to prevent respiratory infections but it is unclear to what extent antigen specific mucosal secretory IgA (SIgA) antibodies are induced by mRNA vaccination in humans. Here we analyze paired serum and saliva samples from patients with and without prior coronavirus disease 2019 (COVID-19) at multiple time points pre and post severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination. Our results suggest mucosal SIgA responses induced by mRNA vaccination are impacted by pre-existing immunity. Indeed, vaccination induced a minimal mucosal SIgA response in individuals without pre-exposure to SARS-CoV-2 while SIgA induction after vaccination was more efficient in patients with a history of COVID-19.

Suggested Citation

  • Kaori Sano & Disha Bhavsar & Gagandeep Singh & Daniel Floda & Komal Srivastava & Charles Gleason & Juan Manuel Carreño & Viviana Simon & Florian Krammer, 2022. "SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32389-8
    DOI: 10.1038/s41467-022-32389-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-32389-8
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-32389-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Teresa Aydillo & Alexander Rombauts & Daniel Stadlbauer & Sadaf Aslam & Gabriela Abelenda-Alonso & Alba Escalera & Fatima Amanat & Kaijun Jiang & Florian Krammer & Jordi Carratala & Adolfo García-Sast, 2021. "Immunological imprinting of the antibody response in COVID-19 patients," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. Weina Sun & Yonghong Liu & Fatima Amanat & Irene González-Domínguez & Stephen McCroskery & Stefan Slamanig & Lynda Coughlan & Victoria Rosado & Nicholas Lemus & Sonia Jangra & Raveen Rathnasinghe & Mi, 2021. "A Newcastle disease virus expressing a stabilized spike protein of SARS-CoV-2 induces protective immune responses," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Elena Mitsi & Mariana O. Diniz & Jesús Reiné & Andrea M. Collins & Ryan E. Robinson & Angela Hyder-Wright & Madlen Farrar & Konstantinos Liatsikos & Josh Hamilton & Onyia Onyema & Britta C. Urban & Ca, 2023. "Respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Stephen M. Kissler & James A. Hay & Joseph R. Fauver & Christina Mack & Caroline G. Tai & Deverick J. Anderson & David D. Ho & Nathan D. Grubaugh & Yonatan H. Grad, 2023. "Viral kinetics of sequential SARS-CoV-2 infections," Nature Communications, Nature, vol. 14(1), pages 1-7, December.
    2. Jakob Ankerhold & Sebastian Giese & Philipp Kolb & Andrea Maul-Pavicic & Reinhard E. Voll & Nathalie Göppert & Kevin Ciminski & Clemens Kreutz & Achim Lother & Ulrich Salzer & Wolfgang Bildl & Tim Wel, 2022. "Circulating multimeric immune complexes contribute to immunopathology in COVID-19," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Carlos Ávila-Nieto & Júlia Vergara-Alert & Pep Amengual-Rigo & Erola Ainsua-Enrich & Marco Brustolin & María Luisa Rodríguez de la Concepción & Núria Pedreño-Lopez & Jordi Rodon & Victor Urrea & Edwar, 2024. "Immunization with V987H-stabilized Spike glycoprotein protects K18-hACE2 mice and golden Syrian hamsters upon SARS-CoV-2 infection," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    4. Brechje Gier & Anne J. Huiberts & Christina E. Hoeve & Gerco Hartog & Henri Werkhoven & Rob Binnendijk & Susan J. M. Hahné & Hester E. Melker & Susan Hof & Mirjam J. Knol, 2023. "Effects of COVID-19 vaccination and previous infection on Omicron SARS-CoV-2 infection and relation with serology," Nature Communications, Nature, vol. 14(1), pages 1-7, December.
    5. Jernej Pušnik & Jasmin Zorn & Werner O. Monzon-Posadas & Kathrin Peters & Emmanuil Osypchuk & Sabine Blaschke & Hendrik Streeck, 2024. "Vaccination impairs de novo immune response to omicron breakthrough infection, a precondition for the original antigenic sin," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    6. Alexander C. Dowell & Tara Lancaster & Rachel Bruton & Georgina Ireland & Christopher Bentley & Panagiota Sylla & Jianmin Zuo & Sam Scott & Azar Jadir & Jusnara Begum & Thomas Roberts & Christine Step, 2023. "Immunological imprinting of humoral immunity to SARS-CoV-2 in children," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    7. Magen E. Francis & Ethan B. Jansen & Anthony Yourkowski & Alaa Selim & Cynthia L. Swan & Brian K. MacPhee & Brittany Thivierge & Rachelle Buchanan & Kerry J. Lavender & Joseph Darbellay & Matthew B. R, 2023. "Previous infection with seasonal coronaviruses does not protect male Syrian hamsters from challenge with SARS-CoV-2," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    8. Irene A. Abela & Chloé Pasin & Magdalena Schwarzmüller & Selina Epp & Michèle E. Sickmann & Merle M. Schanz & Peter Rusert & Jacqueline Weber & Stefan Schmutz & Annette Audigé & Liridona Maliqi & Anni, 2021. "Multifactorial seroprofiling dissects the contribution of pre-existing human coronaviruses responses to SARS-CoV-2 immunity," Nature Communications, Nature, vol. 12(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32389-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.