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Immunological imprinting of the antibody response in COVID-19 patients

Author

Listed:
  • Teresa Aydillo

    (Icahn School of Medicine at Mount Sinai
    Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai)

  • Alexander Rombauts

    (University of Barcelona, L’Hospitalet de Llobregat
    Spanish Network for Research on Infectious Diseases (REIPI, RD16/0016, Carlos III Health Institute)

  • Daniel Stadlbauer

    (Icahn School of Medicine at Mount Sinai)

  • Sadaf Aslam

    (Icahn School of Medicine at Mount Sinai
    Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai)

  • Gabriela Abelenda-Alonso

    (University of Barcelona, L’Hospitalet de Llobregat
    Spanish Network for Research on Infectious Diseases (REIPI, RD16/0016, Carlos III Health Institute)

  • Alba Escalera

    (Icahn School of Medicine at Mount Sinai
    Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai
    Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai)

  • Fatima Amanat

    (Icahn School of Medicine at Mount Sinai
    Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai)

  • Kaijun Jiang

    (Icahn School of Medicine at Mount Sinai)

  • Florian Krammer

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Jordi Carratala

    (University of Barcelona, L’Hospitalet de Llobregat
    Spanish Network for Research on Infectious Diseases (REIPI, RD16/0016, Carlos III Health Institute)

  • Adolfo García-Sastre

    (Icahn School of Medicine at Mount Sinai
    Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai
    The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai)

Abstract

In addition to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), humans are also susceptible to six other coronaviruses, for which consecutive exposures to antigenically related and divergent seasonal coronaviruses are frequent. Despite the prevalence of COVID-19 pandemic and ongoing research, the nature of the antibody response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unclear. Here we longitudinally profile the early humoral immune response against SARS-CoV-2 in hospitalized coronavirus disease 2019 (COVID-19) patients and quantify levels of pre-existing immunity to OC43, HKU1 and 229E seasonal coronaviruses, and find a strong back-boosting effect to conserved but not variable regions of OC43 and HKU1 betacoronaviruses spike protein. However, such antibody memory boost to human coronaviruses negatively correlates with the induction of IgG and IgM against SARS-CoV-2 spike and nucleocapsid protein. Our findings thus provide evidence of immunological imprinting by previous seasonal coronavirus infections that can potentially modulate the antibody profile to SARS-CoV-2 infection.

Suggested Citation

  • Teresa Aydillo & Alexander Rombauts & Daniel Stadlbauer & Sadaf Aslam & Gabriela Abelenda-Alonso & Alba Escalera & Fatima Amanat & Kaijun Jiang & Florian Krammer & Jordi Carratala & Adolfo García-Sast, 2021. "Immunological imprinting of the antibody response in COVID-19 patients," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23977-1
    DOI: 10.1038/s41467-021-23977-1
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    Cited by:

    1. Kaori Sano & Disha Bhavsar & Gagandeep Singh & Daniel Floda & Komal Srivastava & Charles Gleason & Juan Manuel Carreño & Viviana Simon & Florian Krammer, 2022. "SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    2. Brechje Gier & Anne J. Huiberts & Christina E. Hoeve & Gerco Hartog & Henri Werkhoven & Rob Binnendijk & Susan J. M. Hahné & Hester E. Melker & Susan Hof & Mirjam J. Knol, 2023. "Effects of COVID-19 vaccination and previous infection on Omicron SARS-CoV-2 infection and relation with serology," Nature Communications, Nature, vol. 14(1), pages 1-7, December.
    3. Alexander C. Dowell & Tara Lancaster & Rachel Bruton & Georgina Ireland & Christopher Bentley & Panagiota Sylla & Jianmin Zuo & Sam Scott & Azar Jadir & Jusnara Begum & Thomas Roberts & Christine Step, 2023. "Immunological imprinting of humoral immunity to SARS-CoV-2 in children," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    4. Irene A. Abela & Chloé Pasin & Magdalena Schwarzmüller & Selina Epp & Michèle E. Sickmann & Merle M. Schanz & Peter Rusert & Jacqueline Weber & Stefan Schmutz & Annette Audigé & Liridona Maliqi & Anni, 2021. "Multifactorial seroprofiling dissects the contribution of pre-existing human coronaviruses responses to SARS-CoV-2 immunity," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    5. Stephen M. Kissler & James A. Hay & Joseph R. Fauver & Christina Mack & Caroline G. Tai & Deverick J. Anderson & David D. Ho & Nathan D. Grubaugh & Yonatan H. Grad, 2023. "Viral kinetics of sequential SARS-CoV-2 infections," Nature Communications, Nature, vol. 14(1), pages 1-7, December.
    6. Magen E. Francis & Ethan B. Jansen & Anthony Yourkowski & Alaa Selim & Cynthia L. Swan & Brian K. MacPhee & Brittany Thivierge & Rachelle Buchanan & Kerry J. Lavender & Joseph Darbellay & Matthew B. R, 2023. "Previous infection with seasonal coronaviruses does not protect male Syrian hamsters from challenge with SARS-CoV-2," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    7. Jakob Ankerhold & Sebastian Giese & Philipp Kolb & Andrea Maul-Pavicic & Reinhard E. Voll & Nathalie Göppert & Kevin Ciminski & Clemens Kreutz & Achim Lother & Ulrich Salzer & Wolfgang Bildl & Tim Wel, 2022. "Circulating multimeric immune complexes contribute to immunopathology in COVID-19," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    8. Jernej Pušnik & Jasmin Zorn & Werner O. Monzon-Posadas & Kathrin Peters & Emmanuil Osypchuk & Sabine Blaschke & Hendrik Streeck, 2024. "Vaccination impairs de novo immune response to omicron breakthrough infection, a precondition for the original antigenic sin," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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