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Re-expression of CA1 and entorhinal activity patterns preserves temporal context memory at long timescales

Author

Listed:
  • Futing Zou

    (University of Oregon)

  • Guo Wanjia

    (University of Oregon)

  • Emily J. Allen

    (University of Minnesota)

  • Yihan Wu

    (University of Minnesota)

  • Ian Charest

    (University of Montreal)

  • Thomas Naselaris

    (University of Minnesota)

  • Kendrick Kay

    (University of Minnesota)

  • Brice A. Kuhl

    (University of Oregon
    University of Oregon)

  • J. Benjamin Hutchinson

    (University of Oregon)

  • Sarah DuBrow

    (University of Oregon
    University of Oregon)

Abstract

Converging, cross-species evidence indicates that memory for time is supported by hippocampal area CA1 and entorhinal cortex. However, limited evidence characterizes how these regions preserve temporal memories over long timescales (e.g., months). At long timescales, memoranda may be encountered in multiple temporal contexts, potentially creating interference. Here, using 7T fMRI, we measured CA1 and entorhinal activity patterns as human participants viewed thousands of natural scene images distributed, and repeated, across many months. We show that memory for an image’s original temporal context was predicted by the degree to which CA1/entorhinal activity patterns from the first encounter with an image were re-expressed during re-encounters occurring minutes to months later. Critically, temporal memory signals were dissociable from predictors of recognition confidence, which were carried by distinct medial temporal lobe expressions. These findings suggest that CA1 and entorhinal cortex preserve temporal memories across long timescales by coding for and reinstating temporal context information.

Suggested Citation

  • Futing Zou & Guo Wanjia & Emily J. Allen & Yihan Wu & Ian Charest & Thomas Naselaris & Kendrick Kay & Brice A. Kuhl & J. Benjamin Hutchinson & Sarah DuBrow, 2023. "Re-expression of CA1 and entorhinal activity patterns preserves temporal context memory at long timescales," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40100-8
    DOI: 10.1038/s41467-023-40100-8
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    References listed on IDEAS

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