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CA1 and CA3 differentially support spontaneous retrieval of episodic contexts within human hippocampal subfields

Author

Listed:
  • Halle R. Dimsdale-Zucker

    (University of California
    University of California)

  • Maureen Ritchey

    (Boston College)

  • Arne D. Ekstrom

    (University of California
    University of California)

  • Andrew P. Yonelinas

    (University of California
    University of California
    University of California)

  • Charan Ranganath

    (University of California
    University of California)

Abstract

The hippocampus plays a critical role in spatial and episodic memory. Mechanistic models predict that hippocampal subfields have computational specializations that differentially support memory. However, there is little empirical evidence suggesting differences between the subfields, particularly in humans. To clarify how hippocampal subfields support human spatial and episodic memory, we developed a virtual reality paradigm where participants passively navigated through houses (spatial contexts) across a series of videos (episodic contexts). We then used multivariate analyses of high-resolution fMRI data to identify neural representations of contextual information during recollection. Multi-voxel pattern similarity analyses revealed that CA1 represented objects that shared an episodic context as more similar than those from different episodic contexts. CA23DG showed the opposite pattern, differentiating between objects encountered in the same episodic context. The complementary characteristics of these subfields explain how we can parse our experiences into cohesive episodes while retaining the specific details that support vivid recollection.

Suggested Citation

  • Halle R. Dimsdale-Zucker & Maureen Ritchey & Arne D. Ekstrom & Andrew P. Yonelinas & Charan Ranganath, 2018. "CA1 and CA3 differentially support spontaneous retrieval of episodic contexts within human hippocampal subfields," Nature Communications, Nature, vol. 9(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02752-1
    DOI: 10.1038/s41467-017-02752-1
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    Cited by:

    1. Futing Zou & Guo Wanjia & Emily J. Allen & Yihan Wu & Ian Charest & Thomas Naselaris & Kendrick Kay & Brice A. Kuhl & J. Benjamin Hutchinson & Sarah DuBrow, 2023. "Re-expression of CA1 and entorhinal activity patterns preserves temporal context memory at long timescales," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Jordan Crivelli-Decker & Alex Clarke & Seongmin A. Park & Derek J. Huffman & Erie D. Boorman & Charan Ranganath, 2023. "Goal-oriented representations in the human hippocampus during planning and navigation," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Yann Vanrobaeys & Utsav Mukherjee & Lucy Langmack & Stacy E. Beyer & Ethan Bahl & Li-Chun Lin & Jacob J. Michaelson & Ted Abel & Snehajyoti Chatterjee, 2023. "Mapping the spatial transcriptomic signature of the hippocampus during memory consolidation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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