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A selective autophagy receptor VISP1 induces symptom recovery by targeting viral silencing suppressors

Author

Listed:
  • Xin Tong

    (China Agricultural University
    China Agricultural University)

  • Jia-Jia Zhao

    (China Agricultural University)

  • Ya-Lan Feng

    (China Agricultural University)

  • Jing-Ze Zou

    (China Agricultural University)

  • Jian Ye

    (Institute of Microbiology, Chinese Academy of Sciences)

  • Junfeng Liu

    (China Agricultural University)

  • Chenggui Han

    (China Agricultural University)

  • Dawei Li

    (China Agricultural University)

  • Xian-Bing Wang

    (China Agricultural University)

Abstract

Selective autophagy is a double-edged sword in antiviral immunity and regulated by various autophagy receptors. However, it remains unclear how to balance the opposite roles by one autophagy receptor. We previously identified a virus-induced small peptide called VISP1 as a selective autophagy receptor that facilitates virus infections by targeting components of antiviral RNA silencing. However, we show here that VISP1 can also inhibit virus infections by mediating autophagic degradation of viral suppressors of RNA silencing (VSRs). VISP1 targets the cucumber mosaic virus (CMV) 2b protein for degradation and attenuates its suppression activity on RNA silencing. Knockout and overexpression of VISP1 exhibit compromised and enhanced resistance against late infection of CMV, respectively. Consequently, VISP1 induces symptom recovery from CMV infection by triggering 2b turnover. VISP1 also targets the C2/AC2 VSRs of two geminiviruses and enhances antiviral immunity. Together, VISP1 induces symptom recovery from severe infections of plant viruses through controlling VSR accumulation.

Suggested Citation

  • Xin Tong & Jia-Jia Zhao & Ya-Lan Feng & Jing-Ze Zou & Jian Ye & Junfeng Liu & Chenggui Han & Dawei Li & Xian-Bing Wang, 2023. "A selective autophagy receptor VISP1 induces symptom recovery by targeting viral silencing suppressors," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39426-0
    DOI: 10.1038/s41467-023-39426-0
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    References listed on IDEAS

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    1. Si Liu & Meijuan Chen & Ruidong Li & Wan-Xiang Li & Amit Gal-On & Zhenyu Jia & Shou-Wei Ding, 2022. "Identification of positive and negative regulators of antiviral RNA interference in Arabidopsis thaliana," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    2. Jonathan D. G. Jones & Jeffery L. Dangl, 2006. "The plant immune system," Nature, Nature, vol. 444(7117), pages 323-329, November.
    3. Fangfang Li & Changwei Zhang & Yinzi Li & Guanwei Wu & Xilin Hou & Xueping Zhou & Aiming Wang, 2018. "Beclin1 restricts RNA virus infection in plants through suppression and degradation of the viral polymerase," Nature Communications, Nature, vol. 9(1), pages 1-17, December.
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