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Viral RNA polymerase as a SUMOylation decoy inhibits RNA quality control to promote potyvirus infection

Author

Listed:
  • Linhao Ge

    (Chinese Academy of Agricultural Sciences)

  • Mingxuan Jia

    (Chinese Academy of Agricultural Sciences)

  • Hongying Shan

    (Chinese Academy of Agricultural Sciences)

  • Weifang Gao

    (Chinese Academy of Agricultural Sciences)

  • Lu Jiang

    (Chinese Academy of Agricultural Sciences
    Hainan University)

  • Hongguang Cui

    (Hainan University)

  • Xiaofei Cheng

    (Northeast Agricultural University)

  • Marilyne Uzest

    (Univ Montpellier, INRAE, CIRAD, Institut Agro, IRD)

  • Xueping Zhou

    (Chinese Academy of Agricultural Sciences
    Zhejiang University)

  • Aiming Wang

    (Agriculture and Agri-Food Canada)

  • Fangfang Li

    (Chinese Academy of Agricultural Sciences)

Abstract

Potyvirids are the largest group of plant RNA viruses. Pelota, a core component of RNA quality controls (RQC), promotes the degradation of potyvirids’ genomic RNA by recognizing a specific G1-2A6-7 motif. Here we demonstrate that the viral RNA-dependent RNA polymerase, NIb, acts as a SUMOylation decoy to effectively reduce Pelota SUMOylation by competing with SCE1 to inhibit Pelota-mediated RQC. TuMV NIb is comprised of two functional SUMO interacting motif (SIM): SIM2 and SIM3. The former is identified as the key site for NIb’s SUMOylation by SUMO3, whereas the latter is responsible for the interaction with SCE1. These two SIMs are conserved among the majority of potyvirids-encoded NIbs. Thus, virus protein-mediated SUMOylation decoy strategy to suppress host defense may be a common feature in plant virus pathosystems. These findings highlight a dynamic interplay between plant defense mechanism and viral counter-strategy by orchestrating the post-translational modifications of virus and host defense components.

Suggested Citation

  • Linhao Ge & Mingxuan Jia & Hongying Shan & Weifang Gao & Lu Jiang & Hongguang Cui & Xiaofei Cheng & Marilyne Uzest & Xueping Zhou & Aiming Wang & Fangfang Li, 2025. "Viral RNA polymerase as a SUMOylation decoy inhibits RNA quality control to promote potyvirus infection," Nature Communications, Nature, vol. 16(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-024-55288-6
    DOI: 10.1038/s41467-024-55288-6
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    References listed on IDEAS

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    1. Melda Tozluoğlu & Ezgi Karaca & Ruth Nussinov & Türkan Haliloğlu, 2010. "A Mechanistic View of the Role of E3 in Sumoylation," PLOS Computational Biology, Public Library of Science, vol. 6(8), pages 1-10, August.
    2. Fangfang Li & Changwei Zhang & Yinzi Li & Guanwei Wu & Xilin Hou & Xueping Zhou & Aiming Wang, 2018. "Beclin1 restricts RNA virus infection in plants through suppression and degradation of the viral polymerase," Nature Communications, Nature, vol. 9(1), pages 1-17, December.
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