IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-39305-8.html
   My bibliography  Save this article

Morphogenesis of starfish polymersomes

Author

Listed:
  • Jiawei Sun

    (Institute for Molecules and Materials, Radboud University)

  • Sandra Kleuskens

    (Institute for Molecules and Materials, Radboud University)

  • Jiabin Luan

    (Institute for Molecules and Materials, Radboud University)

  • Danni Wang

    (Institute for Molecules and Materials, Radboud University)

  • Shaohua Zhang

    (Institute for Molecules and Materials, Radboud University)

  • Wei Li

    (Institute for Molecules and Materials, Radboud University)

  • Gizem Uysal

    (Institute for Molecules and Materials, Radboud University)

  • Daniela A. Wilson

    (Institute for Molecules and Materials, Radboud University)

Abstract

The enhanced membrane stability and chemical versatility of polymeric vesicles have made them promising tools in micro/nanoreactors, drug delivery, cell mimicking, etc. However, shape control over polymersomes remains a challenge and has restricted their full potential. Here we show that local curvature formation on the polymeric membrane can be controlled by applying poly(N-isopropylacrylamide) as a responsive hydrophobic unit, while adding salt ions to modulate the properties of poly(N-isopropylacrylamide) and its interaction with the polymeric membrane. Polymersomes with multiple arms are fabricated, and the number of arms could be tuned by salt concentration. Furthermore, the salt ions are shown to have a thermodynamic effect on the insertion of poly(N-isopropylacrylamide) into the polymeric membrane. This controlled shape transformation can provide evidence for studying the role of salt ions in curvature formation on polymeric membranes and biomembranes. Moreover, potential stimuli-responsive non-spherical polymersomes can be good candidates for various applications, especially in nanomedicine.

Suggested Citation

  • Jiawei Sun & Sandra Kleuskens & Jiabin Luan & Danni Wang & Shaohua Zhang & Wei Li & Gizem Uysal & Daniela A. Wilson, 2023. "Morphogenesis of starfish polymersomes," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39305-8
    DOI: 10.1038/s41467-023-39305-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-39305-8
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-39305-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Jordan J. Green & Jennifer H. Elisseeff, 2016. "Mimicking biological functionality with polymers for biomedical applications," Nature, Nature, vol. 540(7633), pages 386-394, December.
    2. Chin Ken Wong & Alexander F. Mason & Martina H. Stenzel & Pall Thordarson, 2017. "Formation of non-spherical polymersomes driven by hydrophobic directional aromatic perylene interactions," Nature Communications, Nature, vol. 8(1), pages 1-10, December.
    3. Jiawei Sun & Sjoerd J. Rijpkema & Jiabin Luan & Shaohua Zhang & Daniela A. Wilson, 2021. "Generating biomembrane-like local curvature in polymersomes via dynamic polymer insertion," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Mei Zhu & Shengliang Wang & Zhenhui Li & Junbo Li & Zhijun Xu & Xiaoman Liu & Xin Huang, 2023. "Tyrosine residues initiated photopolymerization in living organisms," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Huanzhi Yang & Yunjun Luo & Bixin Jin & Shumeng Chi & Xiaoyu Li, 2024. "Convoluted micellar morphological transitions driven by tailorable mesogenic ordering effect from discotic mesogen-containing block copolymer," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    3. Dong-Hyun Kang & Won Bae Han & Hyun Ryu & Nam Hyuk Kim & Tae Young Kim & Nakwon Choi & Ji Yoon Kang & Yeon Gyu Yu & Tae Song Kim, 2022. "Tunable and scalable fabrication of block copolymer-based 3D polymorphic artificial cell membrane array," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    4. Yihong Zhong & Lijia Xu & Chen Yang & Le Xu & Guyu Wang & Yuna Guo & Songtao Cheng & Xiao Tian & Changjiang Wang & Ran Xie & Xiaojian Wang & Lin Ding & Huangxian Ju, 2023. "Site-selected in situ polymerization for living cell surface engineering," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    5. Yin Chen & Peng Gao & Lu Huang & Xing Tan & Ningling Zhou & Tong Yang & Hua Qiu & Xin Dai & Sean Michael & Qiufen Tu & Nan Huang & Zhihong Guo & Jianhua Zhou & Zhilu Yang & Hongkai Wu, 2021. "A tough nitric oxide-eluting hydrogel coating suppresses neointimal hyperplasia on vascular stent," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    6. Xiaokang Zhang & Mengkui Cui & Shuoshuo Wang & Fei Han & Pingping Xu & Luyao Teng & Hang Zhao & Ping Wang & Guichu Yue & Yong Zhao & Guangfeng Liu & Ke Li & Jicong Zhang & Xiaoping Liang & Yingying Zh, 2022. "Extensible and self-recoverable proteinaceous materials derived from scallop byssal thread," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39305-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.