IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-28960-y.html
   My bibliography  Save this article

Tunable and scalable fabrication of block copolymer-based 3D polymorphic artificial cell membrane array

Author

Listed:
  • Dong-Hyun Kang

    (Korea Institute of Science and Technology
    Korea Institute of Science and Technology)

  • Won Bae Han

    (Korea Institute of Science and Technology
    Korea University)

  • Hyun Ryu

    (Korea Institute of Science and Technology)

  • Nam Hyuk Kim

    (Kookmin University)

  • Tae Young Kim

    (Korea Institute of Science and Technology)

  • Nakwon Choi

    (Korea Institute of Science and Technology
    Korea University)

  • Ji Yoon Kang

    (Korea Institute of Science and Technology)

  • Yeon Gyu Yu

    (Kookmin University)

  • Tae Song Kim

    (Korea Institute of Science and Technology)

Abstract

Owing to their excellent durability, tunable physical properties, and biofunctionality, block copolymer-based membranes provide a platform for various biotechnological applications. However, conventional approaches for fabricating block copolymer membranes produce only planar or suspended polymersome structures, which limits their utilization. This study is the first to demonstrate that an electric-field-assisted self-assembly technique can allow controllable and scalable fabrication of 3-dimensional block copolymer artificial cell membranes (3DBCPMs) immobilized on predefined locations. Topographically and chemically structured microwell array templates facilitate uniform patterning of block copolymers and serve as reactors for the effective growth of 3DBCPMs. Modulating the concentration of the block copolymer and the amplitude/frequency of the electric field generates 3DBCPMs with diverse shapes, controlled sizes, and high stability (100% survival over 50 days). In vitro protein–membrane assays and mimicking of human intestinal organs highlight the potential of 3DBCPMs for a variety of biological applications such as artificial cells, cell-mimetic biosensors, and bioreactors.

Suggested Citation

  • Dong-Hyun Kang & Won Bae Han & Hyun Ryu & Nam Hyuk Kim & Tae Young Kim & Nakwon Choi & Ji Yoon Kang & Yeon Gyu Yu & Tae Song Kim, 2022. "Tunable and scalable fabrication of block copolymer-based 3D polymorphic artificial cell membrane array," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28960-y
    DOI: 10.1038/s41467-022-28960-y
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-28960-y
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-28960-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Chin Ken Wong & Alexander F. Mason & Martina H. Stenzel & Pall Thordarson, 2017. "Formation of non-spherical polymersomes driven by hydrophobic directional aromatic perylene interactions," Nature Communications, Nature, vol. 8(1), pages 1-10, December.
    2. Claire Ainsworth, 2007. "Tails of the unexpected," Nature, Nature, vol. 448(7154), pages 638-641, August.
    3. Ivan Terzic & Niels L. Meereboer & Mónica Acuautla & Giuseppe Portale & Katja Loos, 2019. "Electroactive materials with tunable response based on block copolymer self-assembly," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Huanzhi Yang & Yunjun Luo & Bixin Jin & Shumeng Chi & Xiaoyu Li, 2024. "Convoluted micellar morphological transitions driven by tailorable mesogenic ordering effect from discotic mesogen-containing block copolymer," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    2. Jiawei Sun & Sandra Kleuskens & Jiabin Luan & Danni Wang & Shaohua Zhang & Wei Li & Gizem Uysal & Daniela A. Wilson, 2023. "Morphogenesis of starfish polymersomes," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28960-y. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.