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Tunable and scalable fabrication of block copolymer-based 3D polymorphic artificial cell membrane array

Author

Listed:
  • Dong-Hyun Kang

    (Korea Institute of Science and Technology
    Korea Institute of Science and Technology)

  • Won Bae Han

    (Korea Institute of Science and Technology
    Korea University)

  • Hyun Ryu

    (Korea Institute of Science and Technology)

  • Nam Hyuk Kim

    (Kookmin University)

  • Tae Young Kim

    (Korea Institute of Science and Technology)

  • Nakwon Choi

    (Korea Institute of Science and Technology
    Korea University)

  • Ji Yoon Kang

    (Korea Institute of Science and Technology)

  • Yeon Gyu Yu

    (Kookmin University)

  • Tae Song Kim

    (Korea Institute of Science and Technology)

Abstract

Owing to their excellent durability, tunable physical properties, and biofunctionality, block copolymer-based membranes provide a platform for various biotechnological applications. However, conventional approaches for fabricating block copolymer membranes produce only planar or suspended polymersome structures, which limits their utilization. This study is the first to demonstrate that an electric-field-assisted self-assembly technique can allow controllable and scalable fabrication of 3-dimensional block copolymer artificial cell membranes (3DBCPMs) immobilized on predefined locations. Topographically and chemically structured microwell array templates facilitate uniform patterning of block copolymers and serve as reactors for the effective growth of 3DBCPMs. Modulating the concentration of the block copolymer and the amplitude/frequency of the electric field generates 3DBCPMs with diverse shapes, controlled sizes, and high stability (100% survival over 50 days). In vitro protein–membrane assays and mimicking of human intestinal organs highlight the potential of 3DBCPMs for a variety of biological applications such as artificial cells, cell-mimetic biosensors, and bioreactors.

Suggested Citation

  • Dong-Hyun Kang & Won Bae Han & Hyun Ryu & Nam Hyuk Kim & Tae Young Kim & Nakwon Choi & Ji Yoon Kang & Yeon Gyu Yu & Tae Song Kim, 2022. "Tunable and scalable fabrication of block copolymer-based 3D polymorphic artificial cell membrane array," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28960-y
    DOI: 10.1038/s41467-022-28960-y
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    References listed on IDEAS

    as
    1. Ivan Terzic & Niels L. Meereboer & Mónica Acuautla & Giuseppe Portale & Katja Loos, 2019. "Electroactive materials with tunable response based on block copolymer self-assembly," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    2. Chin Ken Wong & Alexander F. Mason & Martina H. Stenzel & Pall Thordarson, 2017. "Formation of non-spherical polymersomes driven by hydrophobic directional aromatic perylene interactions," Nature Communications, Nature, vol. 8(1), pages 1-10, December.
    3. Claire Ainsworth, 2007. "Tails of the unexpected," Nature, Nature, vol. 448(7154), pages 638-641, August.
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