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Formation of non-spherical polymersomes driven by hydrophobic directional aromatic perylene interactions

Author

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  • Chin Ken Wong

    (University of New South Wales
    University of New South Wales
    University of New South Wales)

  • Alexander F. Mason

    (University of New South Wales
    University of New South Wales)

  • Martina H. Stenzel

    (University of New South Wales
    University of New South Wales)

  • Pall Thordarson

    (University of New South Wales
    University of New South Wales)

Abstract

Polymersomes, made up of amphiphilic block copolymers, are emerging as a powerful tool in drug delivery and synthetic biology due to their high stability, chemical versatility, and surface modifiability. The full potential of polymersomes, however, has been hindered by a lack of versatile methods for shape control. Here we show that a range of non-spherical polymersome morphologies with anisotropic membranes can be obtained by exploiting hydrophobic directional aromatic interactions between perylene polymer units within the membrane structure. By controlling the extent of solvation/desolvation of the aromatic side chains through changes in solvent quality, we demonstrate facile access to polymersomes that are either ellipsoidal or tubular-shaped. Our results indicate that perylene aromatic interactions have a great potential in the design of non-spherical polymersomes and other structurally complex self-assembled polymer structures.

Suggested Citation

  • Chin Ken Wong & Alexander F. Mason & Martina H. Stenzel & Pall Thordarson, 2017. "Formation of non-spherical polymersomes driven by hydrophobic directional aromatic perylene interactions," Nature Communications, Nature, vol. 8(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01372-z
    DOI: 10.1038/s41467-017-01372-z
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    Cited by:

    1. Jiawei Sun & Sandra Kleuskens & Jiabin Luan & Danni Wang & Shaohua Zhang & Wei Li & Gizem Uysal & Daniela A. Wilson, 2023. "Morphogenesis of starfish polymersomes," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Huanzhi Yang & Yunjun Luo & Bixin Jin & Shumeng Chi & Xiaoyu Li, 2024. "Convoluted micellar morphological transitions driven by tailorable mesogenic ordering effect from discotic mesogen-containing block copolymer," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    3. Dong-Hyun Kang & Won Bae Han & Hyun Ryu & Nam Hyuk Kim & Tae Young Kim & Nakwon Choi & Ji Yoon Kang & Yeon Gyu Yu & Tae Song Kim, 2022. "Tunable and scalable fabrication of block copolymer-based 3D polymorphic artificial cell membrane array," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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