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A tough nitric oxide-eluting hydrogel coating suppresses neointimal hyperplasia on vascular stent

Author

Listed:
  • Yin Chen

    (Sun Yat-sen University
    The Hong Kong University of Science and Technology)

  • Peng Gao

    (Southwest Jiaotong University)

  • Lu Huang

    (Sun Yat-sen University)

  • Xing Tan

    (Southwest Jiaotong University)

  • Ningling Zhou

    (Southwest Jiaotong University)

  • Tong Yang

    (Southwest Jiaotong University)

  • Hua Qiu

    (Southwest Jiaotong University)

  • Xin Dai

    (The Hong Kong University of Science and Technology)

  • Sean Michael

    (The Hong Kong University of Science and Technology)

  • Qiufen Tu

    (Southwest Jiaotong University)

  • Nan Huang

    (Southwest Jiaotong University)

  • Zhihong Guo

    (The Hong Kong University of Science and Technology)

  • Jianhua Zhou

    (Sun Yat-sen University
    Division of Engineering in Medicine, Brigham and Women’s Hospital, Harvard Medical School)

  • Zhilu Yang

    (Southwest Jiaotong University)

  • Hongkai Wu

    (The Hong Kong University of Science and Technology)

Abstract

Vascular stent is viewed as one of the greatest advancements in interventional cardiology. However, current approved stents suffer from in-stent restenosis associated with neointimal hyperplasia or stent thrombosis. Herein, we develop a nitric oxide-eluting (NOE) hydrogel coating for vascular stents inspired by the biological functions of nitric oxide for cardiovascular system. Our NOE hydrogel is mechanically tough and could selectively facilitate the adhesion of endothelial cells. Besides, it is non-thrombotic and capable of inhibiting smooth muscle cells. Transcriptome analysis unravels the NOE hydrogel could modulate the inflammatory response and induce the relaxation of smooth muscle cells. In vivo study further demonstrates vascular stents coated with it promote rapid restoration of native endothelium, and persistently suppress inflammation and neointimal hyperplasia in both leporine and swine models. We expect such NOE hydrogel will open an avenue to the surface engineering of vascular implants for better clinical outcomes.

Suggested Citation

  • Yin Chen & Peng Gao & Lu Huang & Xing Tan & Ningling Zhou & Tong Yang & Hua Qiu & Xin Dai & Sean Michael & Qiufen Tu & Nan Huang & Zhihong Guo & Jianhua Zhou & Zhilu Yang & Hongkai Wu, 2021. "A tough nitric oxide-eluting hydrogel coating suppresses neointimal hyperplasia on vascular stent," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27368-4
    DOI: 10.1038/s41467-021-27368-4
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    References listed on IDEAS

    as
    1. Qingxin Yao & Feng Lin & Xinyuan Fan & Yanpu Wang & Ye Liu & Zhaofei Liu & Xingyu Jiang & Peng R. Chen & Yuan Gao, 2018. "Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems," Nature Communications, Nature, vol. 9(1), pages 1-9, December.
    2. Jordan J. Green & Jennifer H. Elisseeff, 2016. "Mimicking biological functionality with polymers for biomedical applications," Nature, Nature, vol. 540(7633), pages 386-394, December.
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    Cited by:

    1. Haoshuang Wu & Li Yang & Rifang Luo & Li Li & Tiantian Zheng & Kaiyang Huang & Yumei Qin & Xia Yang & Xingdong Zhang & Yunbing Wang, 2024. "A drug-free cardiovascular stent functionalized with tailored collagen supports in-situ healing of vascular tissues," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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