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Association of gout with brain reserve and vulnerability to neurodegenerative disease

Author

Listed:
  • Anya Topiwala

    (University of Oxford)

  • Kulveer Mankia

    (Chapel Allerton Hospital)

  • Steven Bell

    (University of Cambridge)

  • Alastair Webb

    (University of Oxford)

  • Klaus P. Ebmeier

    (University of Oxford, Warneford Hospital)

  • Isobel Howard

    (University of Oxford)

  • Chaoyue Wang

    (University of Oxford
    SJTU-Ruijin-UIH Institute for Medical Imaging Technology)

  • Fidel Alfaro-Almagro

    (University of Oxford)

  • Karla Miller

    (University of Oxford)

  • Stephen Burgess

    (University of Cambridge
    University of Cambridge)

  • Stephen Smith

    (University of Oxford)

  • Thomas E. Nichols

    (University of Oxford
    University of Oxford)

Abstract

Studies of neurodegenerative disease risk in gout are contradictory. Relationships with neuroimaging markers of brain structure, which may offer insights, are uncertain. Here we investigated associations between gout, brain structure, and neurodegenerative disease incidence. Gout patients had smaller global and regional brain volumes and markers of higher brain iron, using both observational and genetic approaches. Participants with gout also had higher incidence of all-cause dementia, Parkinson’s disease, and probable essential tremor. Risks were strongly time dependent, whereby associations with incident dementia were highest in the first 3 years after gout diagnosis. These findings suggest gout is causally related to several measures of brain structure. Lower brain reserve amongst gout patients may explain their higher vulnerability to multiple neurodegenerative diseases. Motor and cognitive impairments may affect gout patients, particularly in early years after diagnosis.

Suggested Citation

  • Anya Topiwala & Kulveer Mankia & Steven Bell & Alastair Webb & Klaus P. Ebmeier & Isobel Howard & Chaoyue Wang & Fidel Alfaro-Almagro & Karla Miller & Stephen Burgess & Stephen Smith & Thomas E. Nicho, 2023. "Association of gout with brain reserve and vulnerability to neurodegenerative disease," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38602-6
    DOI: 10.1038/s41467-023-38602-6
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    References listed on IDEAS

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    1. Marcus R. Munafò & George Davey Smith, 2018. "Robust research needs many lines of evidence," Nature, Nature, vol. 553(7689), pages 399-401, January.
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    Cited by:

    1. Ruo-Han Hao & Tian-Pei Zhang & Feng Jiang & Jun-Hui Liu & Shan-Shan Dong & Meng Li & Yan Guo & Tie-Lin Yang, 2024. "Revealing brain cell-stratified causality through dissecting causal variants according to their cell-type-specific effects on gene expression," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    2. Chengyu Yin & Boyu Liu & Zishan Dong & Sai Shi & Chenxing Peng & Yushuang Pan & Xiaochen Bi & Huimin Nie & Yunwen Zhang & Yan Tai & Qimiao Hu & Xuan Wang & Xiaomei Shao & Hailong An & Jianqiao Fang & , 2024. "CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint pain and inflammation in experimental gouty arthritis," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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