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The thioesterase APT1 is a bidirectional-adjustment redox sensor

Author

Listed:
  • Tuo Ji

    (China Agricultural University)

  • Lihua Zheng

    (China Agricultural University)

  • Jiale Wu

    (China Agricultural University)

  • Mei Duan

    (China Agricultural University)

  • Qianwen Liu

    (China Agricultural University)

  • Peng Liu

    (China Agricultural University)

  • Chen Shen

    (China Agricultural University)

  • Jinling Liu

    (China Agricultural University)

  • Qinyi Ye

    (China Agricultural University)

  • Jiangqi Wen

    (Oklahoma State University
    Oklahoma State University)

  • Jiangli Dong

    (China Agricultural University)

  • Tao Wang

    (China Agricultural University)

Abstract

The adjustment of cellular redox homeostasis is essential in when responding to environmental perturbations, and the mechanism by which cells distinguish between normal and oxidized states through sensors is also important. In this study, we found that acyl-protein thioesterase 1 (APT1) is a redox sensor. Under normal physiological conditions, APT1 exists as a monomer through S-glutathionylation at C20, C22 and C37, which inhibits its enzymatic activity. Under oxidative conditions, APT1 senses the oxidative signal and is tetramerized, which makes it functional. Tetrameric APT1 depalmitoylates S-acetylated NAC (NACsa), and NACsa relocates to the nucleus, increases the cellular glutathione/oxidized glutathione (GSH/GSSG) ratio through the upregulation of glyoxalase I expression, and resists oxidative stress. When oxidative stress is alleviated, APT1 is found in monomeric form. Here, we describe a mechanism through which APT1 mediates a fine-tuned and balanced intracellular redox system in plant defence responses to biotic and abiotic stresses and provide insights into the design of stress-resistant crops.

Suggested Citation

  • Tuo Ji & Lihua Zheng & Jiale Wu & Mei Duan & Qianwen Liu & Peng Liu & Chen Shen & Jinling Liu & Qinyi Ye & Jiangqi Wen & Jiangli Dong & Tao Wang, 2023. "The thioesterase APT1 is a bidirectional-adjustment redox sensor," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38464-y
    DOI: 10.1038/s41467-023-38464-y
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    1. Jae-Hoon Jung & Antonio D. Barbosa & Stephanie Hutin & Janet R. Kumita & Mingjun Gao & Dorothee Derwort & Catarina S. Silva & Xuelei Lai & Elodie Pierre & Feng Geng & Sol-Bi Kim & Sujeong Baek & Chloe, 2020. "A prion-like domain in ELF3 functions as a thermosensor in Arabidopsis," Nature, Nature, vol. 585(7824), pages 256-260, September.
    2. Kai Yang & Ming Wang & Yuzheng Zhao & Xuxu Sun & Yi Yang & Xie Li & Aiwu Zhou & Huilin Chu & Hu Zhou & Jianrong Xu & Mian Wu & Jie Yang & Jing Yi, 2016. "A redox mechanism underlying nucleolar stress sensing by nucleophosmin," Nature Communications, Nature, vol. 7(1), pages 1-16, December.
    3. Alba Luengo & Keene L. Abbott & Shawn M. Davidson & Aaron M. Hosios & Brandon Faubert & Sze Ham Chan & Elizaveta Freinkman & Lauren G. Zacharias & Thomas P. Mathews & Clary B. Clish & Ralph J. DeBerar, 2019. "Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    4. Feihua Wu & Yuan Chi & Zhonghao Jiang & Yuanyuan Xu & Ling Xie & Feifei Huang & Di Wan & Jun Ni & Fang Yuan & Xiaomei Wu & Yanyan Zhang & Li Wang & Rui Ye & Benjamin Byeon & Wenhua Wang & Shu Zhang & , 2020. "Hydrogen peroxide sensor HPCA1 is an LRR receptor kinase in Arabidopsis," Nature, Nature, vol. 578(7796), pages 577-581, February.
    5. Olivier Hamant & Daisuke Inoue & David Bouchez & Jacques Dumais & Eric Mjolsness, 2019. "Are microtubules tension sensors?," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    6. Jianhua Zhao & John V. Lin King & Candice E. Paulsen & Yifan Cheng & David Julius, 2020. "Irritant-evoked activation and calcium modulation of the TRPA1 receptor," Nature, Nature, vol. 585(7823), pages 141-145, September.
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