IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-37319-w.html
   My bibliography  Save this article

Purkinje cell dopaminergic inputs to astrocytes regulate cerebellar-dependent behavior

Author

Listed:
  • Chang Li

    (University of Alabama at Birmingham)

  • Natalie B. Saliba

    (University of Alabama at Birmingham)

  • Hannah Martin

    (University of Alabama at Birmingham
    University Medical Center Göttingen)

  • Nicole A. Losurdo

    (University of Alabama at Birmingham
    The University of Utah)

  • Kian Kolahdouzan

    (University of Alabama at Birmingham)

  • Riyan Siddiqui

    (University of Alabama at Birmingham)

  • Destynie Medeiros

    (University of Alabama at Birmingham)

  • Wei Li

    (University of Alabama at Birmingham)

Abstract

Dopamine has a significant role in motor and cognitive function. The dopaminergic pathways originating from the midbrain have received the most attention; however, the relevance of the cerebellar dopaminergic system is largely undiscovered. Here, we show that the major cerebellar astrocyte type Bergmann glial cells express D1 receptors. Dopamine can be synthesized in Purkinje cells by cytochrome P450 and released in an activity-dependent fashion. We demonstrate that activation of D1 receptors induces membrane depolarization and Ca2+ release from the internal store. These astrocytic activities in turn modify Purkinje cell output by altering its excitatory and inhibitory synaptic input. Lastly, we show that conditional knockout of D1 receptors in Bergmann glial cells results in decreased locomotor activity and impaired social activity. These results contribute to the understanding of the molecular, cellular, and circuit mechanisms underlying dopamine function in the cerebellum, revealing a critical role for the cerebellar dopaminergic system in motor and social behavior.

Suggested Citation

  • Chang Li & Natalie B. Saliba & Hannah Martin & Nicole A. Losurdo & Kian Kolahdouzan & Riyan Siddiqui & Destynie Medeiros & Wei Li, 2023. "Purkinje cell dopaminergic inputs to astrocytes regulate cerebellar-dependent behavior," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37319-w
    DOI: 10.1038/s41467-023-37319-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-37319-w
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-023-37319-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Wei Shao & Shu-zhen Zhang & Mi Tang & Xin-hua Zhang & Zheng Zhou & Yan-qing Yin & Qin-bo Zhou & Yuan-yuan Huang & Ying-jun Liu & Eric Wawrousek & Teng Chen & Sheng-bin Li & Ming Xu & Jiang-ning Zhou &, 2013. "Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin," Nature, Nature, vol. 494(7435), pages 90-94, February.
    2. Shiaoching Gong & Chen Zheng & Martin L. Doughty & Kasia Losos & Nicholas Didkovsky & Uta B. Schambra & Norma J. Nowak & Alexandra Joyner & Gabrielle Leblanc & Mary E. Hatten & Nathaniel Heintz, 2003. "A gene expression atlas of the central nervous system based on bacterial artificial chromosomes," Nature, Nature, vol. 425(6961), pages 917-925, October.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Myung Chung & Katsutoshi Imanaka & Ziyan Huang & Akiyuki Watarai & Mu-Yun Wang & Kentaro Tao & Hirotaka Ejima & Tomomi Aida & Guoping Feng & Teruhiro Okuyama, 2024. "Conditional knockout of Shank3 in the ventral CA1 by quantitative in vivo genome-editing impairs social memory in mice," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    2. Brandon W. Hughes & Jessica L. Huebschman & Evgeny Tsvetkov & Benjamin M. Siemsen & Kirsten K. Snyder & Rose Marie Akiki & Daniel J. Wood & Rachel D. Penrod & Michael D. Scofield & Stefano Berto & Mak, 2024. "NPAS4 supports cocaine-conditioned cues in rodents by controlling the cell type-specific activation balance in the nucleus accumbens," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Terra A. Schall & King-Lun Li & Xiguang Qi & Brian T. Lee & William J. Wright & Erin E. Alpaugh & Rachel J. Zhao & Jianwei Liu & Qize Li & Bo Zeng & Lirong Wang & Yanhua H. Huang & Oliver M. Schlüter , 2024. "Temporal dynamics of nucleus accumbens neurons in male mice during reward seeking," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    4. Clara Morral & Arshad Ayyaz & Hsuan-Cheng Kuo & Mardi Fink & Ioannis I. Verginadis & Andrea R. Daniel & Danielle N. Burner & Lucy M. Driver & Sloane Satow & Stephanie Hasapis & Reem Ghinnagow & Lixia , 2024. "p53 promotes revival stem cells in the regenerating intestine after severe radiation injury," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    5. Sofia Madsen & Ana C. Delgado & Christelle Cadilhac & Vanille Maillard & Fabrice Battiston & Carla Marie Igelbüscher & Simon De Neck & Elia Magrinelli & Denis Jabaudon & Ludovic Telley & Fiona Doetsch, 2024. "A fluorescent perilipin 2 knock-in mouse model reveals a high abundance of lipid droplets in the developing and adult brain," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    6. Yun-Feng Zhang & Jialiang Wu & Yingqi Wang & Natalie L. Johnson & Janardhan P. Bhattarai & Guanqing Li & Wenqiang Wang & Camilo Guevara & Hannah Shoenhard & Marc V. Fuccillo & Daniel W. Wesson & Mingh, 2023. "Ventral striatal islands of Calleja neurons bidirectionally mediate depression-like behaviors in mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    7. Paul B Manis & Michael R Kasten & Ruili Xie, 2019. "Classification of neurons in the adult mouse cochlear nucleus: Linear discriminant analysis," PLOS ONE, Public Library of Science, vol. 14(10), pages 1-14, October.
    8. Gwen-Jirō Clochard & Aby Mbengue & Clément Mettling & Birane Diouf & Charlotte Faurie & Omar Sene & Emilie Chancerel & Erwan Guichoux & Guillaume Hollard & Michel Raymond & Marc Willinger, 2023. "The effect of the 7R allele at the DRD4 locus on risk tolerance is independent of background risk in Senegalese fishermen," Post-Print hal-03954770, HAL.
    9. Jong Hoon Won & Jacob S. Choi & Joon-Il Jun, 2022. "CCN1 interacts with integrins to regulate intestinal stem cell proliferation and differentiation," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    10. Fan Mei & Chen Zhao & Shangjin Li & Zeping Xue & Yueyang Zhao & Yihua Xu & Rongrong Ye & He You & Peng Yu & Xinyu Han & Gregory V. Carr & Daniel R. Weinberger & Feng Yang & Bai Lu, 2024. "Ngfr+ cholinergic projection from SI/nBM to mPFC selectively regulates temporal order recognition memory," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    11. Chikako Nakajima & Masato Sawada & Erika Umeda & Yuma Takagi & Norihiko Nakashima & Kazuya Kuboyama & Naoko Kaneko & Satoaki Yamamoto & Haruno Nakamura & Naoki Shimada & Koichiro Nakamura & Kumiko Mat, 2024. "Identification of the growth cone as a probe and driver of neuronal migration in the injured brain," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    12. Josephine A. Mapunda & Javier Pareja & Mykhailo Vladymyrov & Elisa Bouillet & Pauline Hélie & Petr Pleskač & Sara Barcos & Johanna Andrae & Dietmar Vestweber & Donald M. McDonald & Christer Betsholtz , 2023. "VE-cadherin in arachnoid and pia mater cells serves as a suitable landmark for in vivo imaging of CNS immune surveillance and inflammation," Nature Communications, Nature, vol. 14(1), pages 1-23, December.
    13. Solomiia Korchynska & Patrick Rebernik & Marko Pende & Laura Boi & Alán Alpár & Ramon Tasan & Klaus Becker & Kira Balueva & Saiedeh Saghafi & Peer Wulff & Tamas L. Horvath & Gilberto Fisone & Hans-Ulr, 2022. "A hypothalamic dopamine locus for psychostimulant-induced hyperlocomotion in mice," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    14. Mehmet Can Uçar & Edouard Hannezo & Emmi Tiilikainen & Inam Liaqat & Emma Jakobsson & Harri Nurmi & Kari Vaahtomeri, 2023. "Self-organized and directed branching results in optimal coverage in developing dermal lymphatic networks," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    15. Matthieu Maroteaux & Emmanuel Valjent & Sophie Longueville & Piotr Topilko & Jean-Antoine Girault & Denis Hervé, 2014. "Role of the Plasticity-Associated Transcription Factor Zif268 in the Early Phase of Instrumental Learning," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-13, January.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37319-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.