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Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin

Author

Listed:
  • Wei Shao

    (Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China)

  • Shu-zhen Zhang

    (Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China)

  • Mi Tang

    (Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, Jiangsu 210029, China)

  • Xin-hua Zhang

    (Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China)

  • Zheng Zhou

    (Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China)

  • Yan-qing Yin

    (Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China)

  • Qin-bo Zhou

    (Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China)

  • Yuan-yuan Huang

    (Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China)

  • Ying-jun Liu

    (Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China)

  • Eric Wawrousek

    (National Eye Institute, NIH)

  • Teng Chen

    (Xi’an Jiaotong University School of Medicine, Xi’an, Shanxi 710061, China)

  • Sheng-bin Li

    (Xi’an Jiaotong University School of Medicine, Xi’an, Shanxi 710061, China)

  • Ming Xu

    (University of Chicago)

  • Jiang-ning Zhou

    (CAS Key Laboratory of Brain Function and Diseases, School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, China)

  • Gang Hu

    (Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, Jiangsu 210029, China)

  • Jia-wei Zhou

    (Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China)

Abstract

Chronic inflammation is a feature of the ageing brain and some neurodegenerative diseases; the authors show that astrocytes normally suppress neuroinflammation through activation of their DRD2 receptor by CRYAB, potentially opening new avenues for treatments.

Suggested Citation

  • Wei Shao & Shu-zhen Zhang & Mi Tang & Xin-hua Zhang & Zheng Zhou & Yan-qing Yin & Qin-bo Zhou & Yuan-yuan Huang & Ying-jun Liu & Eric Wawrousek & Teng Chen & Sheng-bin Li & Ming Xu & Jiang-ning Zhou &, 2013. "Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin," Nature, Nature, vol. 494(7435), pages 90-94, February.
    • Handle: RePEc:nat:nature:v:494:y:2013:i:7435:d:10.1038_nature11748
    DOI: 10.1038/nature11748
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    Cited by:

    1. Chang Li & Natalie B. Saliba & Hannah Martin & Nicole A. Losurdo & Kian Kolahdouzan & Riyan Siddiqui & Destynie Medeiros & Wei Li, 2023. "Purkinje cell dopaminergic inputs to astrocytes regulate cerebellar-dependent behavior," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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